Role of Cord Factor (trehalose-6,6'-dimycolate) in Allergic Granuloma Formation in Rabbits

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1972 Jul 1

PMID 4564153

Citations 8

Authors

V L Moore

Q N Myrvik

M Kato

Affiliations

Soon will be listed here.

Abstract

The role of cord factor in BCG-induced pulmonary granulomas and local pulmonary delayed hypersensitivity (DH) was evaluated. Cord factor did not induce pulmonary granulomas comparable to those induced by killed BCG. The compound did not induce pulmonary DH that could be elicited by itself, purified protein derivative, or BCG. Cord factor-injected animals did not develop an accelerated pulmonary granulomatous response after challenge with killed BCG. Finally, cord factor did not elicit local pulmonary DH in BCG-sensitized animals. These results are discussed in relation to cord factor's role in antimicrobial immunity, granuloma formation, and antitumor immunity.

Citing Articles

Interstitial and hemorrhagic pneumonitis induced by mycobacterial trehalose dimycolate.

Seggev J, Goren M, Carr R, Kirkpatrick C Am J Pathol. 1982; 106(3):348-55.

PMID: 6801989 PMC: 1916212.

Specificity of a BCG-induced pulmonary granulomatous response in rabbits.

Moore V, Myrvik Q, LEAKE E Infect Immun. 1973; 7(5):743-6.

PMID: 4764403 PMC: 422754. DOI: 10.1128/iai.7.5.743-746.1973.

Granulomatous hypersensitivity to trehalose-6,6'-dimycolate (cord factor) in mice infected with BCG.

Bekierkunst A, Yarkoni E Infect Immun. 1973; 7(4):631-8.

PMID: 4586862 PMC: 422736. DOI: 10.1128/iai.7.4.631-638.1973.

Mycobacterial components responsible for the induction of a chronic immunological inflammatory response in rabbit lungs.

Moore V, Myrvik Q Infect Immun. 1974; 10(1):21-4.

PMID: 4210331 PMC: 414950. DOI: 10.1128/iai.10.1.21-24.1974.

Granuloma formation by muramyl dipeptide associated with branched fatty acids, a structure probably essential for tubercle formation by Mycobacterium tuberculosis.

Emori K, Nagao S, Shigematsu N, Kotani S, Tsujimoto M, Shiba T Infect Immun. 1985; 49(1):244-9.

PMID: 3924828 PMC: 262085. DOI: 10.1128/iai.49.1.244-249.1985.

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