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Acute Granulomatous Response Produced in Mice by Trehalose-6,6-dimycolate

Overview
Journal J Bacteriol
Publisher American Society for Microbiology
Specialty Microbiology
Date 1968 Oct 1
PMID 4971895
Citations 32
Authors
A Bekierkunst
Affiliations
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Abstract

Trehalose-6,6-dimycolate, a toxic lipid derived from tubercle bacilli, injected intravenously into mice in 10% emulsions of Bayol F caused a three- to fourfold increase in the weights of lungs compared with those of mice injected with emulsions of Bayol F alone or emulsions of Wax D. This change is due to a heavy infiltration of the lungs with granulocytes and large numbers of macrophages, with formation in some of the infiltrates of round foci, resembling granulomas.

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References
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