Splenic Replenishment of Synergistic Ability to Bone Marrow and Thymic Cells of Neonatally Splenectomized CBA Mice

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1972 Oct 1

PMID 4560344

Citations 5

Authors

R A Bucsi

F Borek

J R BATTISTO

Affiliations

Soon will be listed here.

Abstract

Bone marrow (B) and thymic (T) cells taken from adult mice that had been splenectomized within 24 hr of birth showed an inability to cooperate in the IgM response to sheep red blood cells. The defect in collaborative capacity was apparent in both sets of cells, but appeared to be more pronounced in the T cell population. Splenectomy performed at various neonatal intervals indicated that if removal of the spleen were delayed until 6 days after birth, B and T cells of the adult showed a 60% restoration in cooperation. Replenishment of the synergistic ability after neonatal splenectomy could be achieved by injecting spleen cells immediately after spleen removal or 2 months postsplenectomy.

Citing Articles

Immune competence of hereditarily asplenic mice.

LOZZIO B, Wargon L Immunology. 1974; 27(2):167-78.

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Immunobiology of congenitally athymic-asplenic mice.

Gershwin M, Ahmed A, Ikeda R, Shifrine M, Wilson F Immunology. 1978; 34(4):631-42.

PMID: 721133 PMC: 1457168.

Infectious agents in immunodeficient murine models: pathogenicity of Nocardia asteroides in congenitally athymic (nude) and hereditarily asplenic (Dh/+) mice.

Beaman B, Gershwin M, Maslan S Infect Immun. 1978; 20(2):381-7.

PMID: 352942 PMC: 421866. DOI: 10.1128/iai.20.2.381-387.1978.

Effects of splenectomy on the humoral immune system. A study in neonatally and adult splenectomized mice.

Rozing J, Brons N, Bennner R Immunology. 1978; 34(5):909-17.

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Comparative patterns of serum immunoglobulin levels in specific-pathogen-free congenitally athymic (nude), hereditarily asplenic (Dh/+), congenitally athymic-asplenic (lasat) and splenectomized athymic mice.

Eckels D, Gershwin M, Drago J, Faulkin L Immunology. 1979; 37(4):777-83.

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