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In Vitro Susceptibility of Haemophilus Influenzae to Trimethoprim-sulfamethoxazole

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 1974 Dec 1
PMID 4548834
Citations 10
Authors
L A Kirven
C Thornsberry
Affiliations
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Abstract

Thirty-four strains of Haemophilus influenzae (20 ampicillin sensitive and 14 ampicillin resistant), mostly type b isolates from cerebrospinal fluid or blood, were tested for susceptibility to a combination of trimethoprim-sulfamethoxazole (TMP-SMZ) in a ratio of 1 part TMP to 19 parts SMZ. All strains were very susceptible to the TMP-SMZ combination, with minimal inhibitory concentrations ranging from 0.007-0.14 to 0.06-1.18 mug of TMP-SMZ per ml. There was little difference in the susceptibility of the ampicillin-sensitive and ampicillin-resistant strains to TMP-SMZ.

Citing Articles

Interpretive criteria and quality control parameters for testing of susceptibilities of Haemophilus influenzae and Streptococcus pneumoniae to trimethoprim and trimethoprim-sulfamethoxazole. The Antimicrobial Susceptibility Testing OC Group.

Fuchs P, Barry A, Brown S J Clin Microbiol. 1997; 35(1):125-31.

PMID: 8968893 PMC: 229524. DOI: 10.1128/jcm.35.1.125-131.1997.

Inoculum standardization in antimicrobial susceptibility testing: evaluation of overnight agar cultures and the Rapid Inoculum Standardization System.

Baker C, Thornsberry C, Hawkinson R J Clin Microbiol. 1983; 17(3):450-7.

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Modified microdilution susceptibility test for staphylococci, streptococci and Haemophilus spp.

Fass R, Helsel V Eur J Clin Microbiol. 1984; 3(4):318-9.

PMID: 6489321 DOI: 10.1007/BF01977481.

Improved medium for antimicrobial susceptibility testing of Haemophilus influenzae.

Jorgensen J, REDDING J, Maher L, Howell A J Clin Microbiol. 1987; 25(11):2105-13.

PMID: 3500965 PMC: 269421. DOI: 10.1128/jcm.25.11.2105-2113.1987.

Influence of growth medium and supplement on growth of Haemophilus influenzae and on antibacterial activity of several antibiotics.

Bergeron M, Simard P, Provencher P J Clin Microbiol. 1987; 25(4):650-5.

PMID: 3494745 PMC: 266053. DOI: 10.1128/jcm.25.4.650-655.1987.

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