On the Identity of DOPA Decarboxylase and 5-hydroxytryptophan Decarboxylase (immunological Titration-aromatic L-amino Acid Decarboxylase-serotonin-dopamine-norepinephrine)

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1972 Feb 1

PMID 4536745

Citations 56

Authors

J G Christenson

W Dairman

S UDENFRIEND

Affiliations

Soon will be listed here.

Abstract

Simultaneous immunological titration of DOPA and 5-hydroxytryptophan decarboxylase activities, from a number of tissues of various species, showed that the two activities were not distinguishable with a monospecific antiserum to hog kidney decarboxylase. Together with previous findings, these data firmly establish the concept that in mammalian tissues the two enzyme activities are associated with a single protein, namely aromatic L-amino acid decarboxylase.

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