Guanosine 5'-diphosphate, 3'-diphosphate: Assignment of Structure by 13C Nuclear Magnetic Resonance Spectroscopy

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1973 Sep 1

PMID 4517670

Citations 4

Authors

L Que Jr

G R Willie

M CASHEL

J W BODLEY

G R Gray

Affiliations

Soon will be listed here.

Abstract

Guanosine tetraphosphate, recently discovered to mediate the regulatory relationship between protein synthesis and RNA accumulation in various bacteria, has been synthesized in vitro in large quantities and analyzed by natural-abundance (13)C nuclear magnetic resonance spectroscopy in order to confirm its structure and establish the positions of phosphate attachment. These studies have established its structure as guanosine 5'-diphosphate, 3'-diphosphate.

Citing Articles

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Role of guanine nucleotides in protein synthesis. Elongation factor G and guanosine 5'-triphosphate,3'-diphosphate.

Hamel E, CASHEL M Proc Natl Acad Sci U S A. 1973; 70(11):3250-4.

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Nucleotide pools and regulation of ribonucleic acid synthesis in yeast.

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