HL-A-linked Human Immune-response Genes

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1973 Jul 1

PMID 4516211

Citations 10

Authors

C E BUCKLEY 3rd

F C Dorsey

R B Corley

W B Ralph

M A Woodbury

D B Amos

Affiliations

Soon will be listed here.

Abstract

Genetic control of the response to specific natural-product antigens has been documented in three informative families. Families were selected on the basis of probands with tuberculosarcoidosis, chronic cutaneous moniliasis, and rheumatoid arthritis. An increased incidence of delayed cutaneous unresponsiveness was observed in each family. Positive associations were identified between HL-A haplotypes and immediate cutaneous hypersensitivity responses to 5, 8, and 11 of 23 test antigens in the three respective families. HL-A-associated differences in averaged responses of cutaneous hypersensitivity were excluded. These significant associations are consistent with linkage between HL-A haplotypes and genes responsible for the immune response to various natural-product antigens.

Citing Articles

Reactivity to spherule-derived coccidioidin in the southeastern United States.

Woodruff 3rd W, BUCKLEY 3rd C, Gallis H, Cohn J, Wheat R Infect Immun. 1984; 43(3):860-9.

PMID: 6199305 PMC: 264262. DOI: 10.1128/iai.43.3.860-869.1984.

HL-A antigens in North American black families.

Ward F, BIEGEL A Am J Hum Genet. 1976; 28(1):1-8.

PMID: 1247016 PMC: 1684898.

Mapping of the immune response genes in the major histocompatibility complex of the Rhesus monkey.

Dorf M, Balner H, Benacerraf B J Exp Med. 1975; 142(3):673-93.

PMID: 1165471 PMC: 2189930. DOI: 10.1084/jem.142.3.673.

The genetic control of the antibody response in inbred rats.

Ruscetti S, Gill 3rd T, Kunz H Mol Cell Biochem. 1975; 7(3):145-56.

PMID: 1152844 DOI: 10.1007/BF01731405.

Association of HL-A 5 and immune responsiveness in vitro to streptococcal antigens.

Greenberg L, Gray E, Yunis E J Exp Med. 1975; 141(5):935-43.

PMID: 1127380 PMC: 2189789. DOI: 10.1084/jem.141.5.935.

References

PINCHUCK P, Maurer P . Antigenicity of polypeptides (poly alpha amino acids). XV. Studies on the immunogenicity of synthetic polypeptides in mice. J Exp Med. 1965; 122(4):665-71. PMC: 2138089. DOI: 10.1084/jem.122.4.665. View

STANWORTH D, Kuhns W . QUANTITATIVE STUDIES ON THE ASSAY OF HUMAN SKIN-SENSITIZING ANTIBODIES (REAGINS). I. AN EXAMINATION OF FACTORS AFFECTING THE ACCURACY OF THE PRAUSNITZ-KUESTNER (P-K) TEST. Immunology. 1965; 8:323-44. PMC: 1423493. View

Palmer C, Edwards L . Identifying the tuberculous infected. The dual-test technique. JAMA. 1968; 205(3):167-9. View

McDevitt H, Benacerraf B . Genetic control of specific immune responses. Adv Immunol. 1969; 11:31-74. DOI: 10.1016/s0065-2776(08)60477-0. View

Vaz N, Vaz E, LEVINE B . Relationship between histocompatibility (H-2) genotype and immune responsiveness to low doses of ovalbumin in the mouse. J Immunol. 1970; 104(6):1572-4. View

Fudenberg H, GOOD R, Goodman H, HITZIG W, KUNKEL H, Roitt I . Primary immunodeficiencies. Report of a World Health Organization Committee. Pediatrics. 1971; 47(5):927-46. View

Pincus T, Rowe W, Lilly F . A major genetic locus affecting resistance to infection with murine leukemia viruses. II. Apparent identity to a major locus described for resistance to friend murine leukemia virus. J Exp Med. 1971; 133(6):1234-41. PMC: 2138931. DOI: 10.1084/jem.133.6.1234. View

Thomas L . "Vibes". N Engl J Med. 1972; 286(2):88-90. DOI: 10.1056/NEJM197201132860210. View

Okumura K, Tada T . Regulation of homocytotropic antibody formation in the rat. VI. Inhibitory effect of thymocytes on the homocytotropic antibody response. J Immunol. 1971; 107(6):1682-9. View

10.

BUCKLEY 3rd C, Dorsey F . Serum immunoglobulin levels throughout the life-span of healthy man. Ann Intern Med. 1971; 75(5):673-82. DOI: 10.7326/0003-4819-75-5-673. View

11.

Yunis E, Amos D . Three closely linked genetic systems relevant to transplantation. Proc Natl Acad Sci U S A. 1971; 68(12):3031-5. PMC: 389584. DOI: 10.1073/pnas.68.12.3031. View

12.

Grundbacher F . Human X chromosome carries quantitative genes for immunoglobulin M. Science. 1972; 176(4032):311-2. DOI: 10.1126/science.176.4032.311. View

13.

WALFORD R, Smith G, Waters H . Histocompatibility systems and disease states with particular reference to cancer. Transplant Rev. 1971; 7:78-111. DOI: 10.1111/j.1600-065x.1971.tb00464.x. View

14.

Martin F, Vilseck J, DOBBINS 3rd W, BUCKLEY 3rd C, TYOR M . Immunological alterations in patients with treated Whipple's disease. Gastroenterology. 1972; 63(1):6-18. View

15.

Gottlieb C, PERKINS E, Makinodan T . Genetic regulation of the thymus dependent humoral immune response in leukemia prone AKR (H-2 k ) and nonleukemic C3H (H-2 k ) mice. Description of genetic control of the immune response at the level of proliferation. J Immunol. 1972; 109(5):974-81. View

16.

LEVINE B, Stember R, Fotino M . Ragweed hay fever: genetic control and linkage to HL-A haplotypes. Science. 1972; 178(4066):1201-3. DOI: 10.1126/science.178.4066.1201. View

17.

BUCKLEY 3rd C, Zitt M, CATE T . Two categories of lymphocyte unresponsiveness to phytohemagglutinin. Cell Immunol. 1973; 6(1):140-8. DOI: 10.1016/0008-8749(73)90014-2. View

18.

Marsh D, Bias W, Hsu S, GOODFRIEND L . Association of the HL-A7 cross-reacting group with a specific reaginic antibody response in allergic man. Science. 1973; 179(4074):691-3. DOI: 10.1126/science.179.4074.691. View

19.

SWAIN H, Becker E . Quantitative studies in skin testing. V. The whealing reactions of histamine and ragweed pollen extract. J Allergy. 1952; 23(5):441-51. DOI: 10.1016/0021-8707(52)90008-7. View

20.

Burnet F . Immunological recognition of self. Science. 1961; 133(3449):307-11. DOI: 10.1126/science.133.3449.307. View