HL-A Antigens in North American Black Families

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 1976 Jan 1

PMID 1247016

Citations 2

Authors

F E Ward

A A BIEGEL

Affiliations

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Abstract

The polymorphic HL-A histocompatibility system has been studied in North American black families. The family studies show that haplotype frequencies differ between black and white populations. Seven haplotypes (W28,W5; W28,W17; W28, undefined four; W23,W5; W19,W5; undefined LA,W5; and undefined LA, undefined four) were significantly more frequent in blacks than whites, while haplotypes 1,8 and 3,7 were significantly less frequent. Some of these differences may be accounted for by differences in gene frequencies between the two groups; other differences may be explained by linkage disequilibrium in the white population. No significant linkage disequilibrium between the LA and FOUR loci was found in the black population.

Citing Articles

HLA antigens in acute anterior uveitis in South African blacks.

Maier G, Miller B, Freedman J, BAUMGARTEN I Br J Ophthalmol. 1980; 64(5):329-31.

PMID: 7192157 PMC: 1043689. DOI: 10.1136/bjo.64.5.329.

HLA antigens in glaucoma and ocular hypertension.

David R, Maier G, BAUMGARTEN I, ABRAHAMS C Br J Ophthalmol. 1979; 63(5):293-6.

PMID: 465401 PMC: 1043474. DOI: 10.1136/bjo.63.5.293.

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