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Location of Ribosomal DNA in the Human Chromosome Complement

Overview
Journal Proc Natl Acad Sci U S A
Specialty Science
Date 1972 Nov 1
PMID 4508329
Citations 272
Authors
A S Henderson
D Warburton
K C Atwood
Affiliations
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Abstract

Hybridization of (3)H-labeled ribosomal RNA to human chromosomes on slides resulted in specific labeling of the satellite regions of chromosomes 13, 14, 15, 21, and 22, with an over-all efficiency of about 5%. Differences between D and G chromosomes, and between associated and unassociated satellites, were not significant. Labeling of all other parts of the preparations was nonspecific, and increased in the order: extrachromosomal regions < chromosome arms < centric regions.

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References
1.
Gall J, Pardue M . Formation and detection of RNA-DNA hybrid molecules in cytological preparations. Proc Natl Acad Sci U S A. 1969; 63(2):378-83. PMC: 223575. DOI: 10.1073/pnas.63.2.378. View
2.
Bross K, Krone W . On the number of ribosomal RNA genes in man. Humangenetik. 1972; 14(2):137-41. DOI: 10.1007/BF00273298. View
3.
Ferguson-Smith M, HANDMAKER S . Observations on the satellited human chromosomes. Lancet. 1961; 1(7178):638-40. DOI: 10.1016/s0140-6736(61)91655-5. View
4.
Ohno S, Trujillo J, Kaplan W, Kinosita R . Nucleolus-organisers in the causation of chromosomal anomalies in man. Lancet. 1961; 2(7194):123-6. DOI: 10.1016/s0140-6736(61)92647-2. View