The Role of Ribosomal DNA Methylation in Embryonic Development, Aging and Diseases

Overview

Journal Epigenetics Chromatin

Publisher Biomed Central

Specialties Biochemistry
Genetics

Date 2024 Jul 31

PMID 39085958

Authors

Fei Yang

Xutong Guo

Yiming Bao

Rujiao Li

Affiliations

Soon will be listed here.

Abstract

The ribosomal DNA (rDNA) constitutes a remarkably conserved DNA sequence within species, located in the area of the nucleolus, and responsible for coding three major types of rRNAs (18S, 5.8S and 28S). While historical investigations into rDNA focused on its structure and coding capabilities, recent research has turned to explore its functional roles in various biological processes. In this review, we summarize the main findings of rDNA methylation with embryonic development, aging and diseases in multiple species, including epigenetic alterations, related biological processes and potential applications of rDNA methylation. We present an overview of current related research and identify gaps in this field.

Citing Articles

Impacts of ribosomal RNA sequence variation on gene expression and phenotype.

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PMID: 40045785 PMC: 11883441. DOI: 10.1098/rstb.2023.0379.

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