Genetic Control of the Antibody Response to Type 3 Pneumococcal Polysaccharide in Mice. I. Evidence That an X-linked Gene Plays a Decisive Role in Determining Responsiveness

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1972 Oct 1

PMID 4403476

Citations 109

Authors

D F Amsbaugh

C T Hansen

B PRESCOTT

P W STASHAK

D R Barthold

P J Baker

Affiliations

Soon will be listed here.

Abstract

The IgM antibody response to Type III pneumococcal polysaccharide (SSS-III) was assessed in F(1), F(2), and backcross progeny derived from high (BALB/cAnN) and extremely low (CBA/HN) responding parental strains of inbred mice. The results of these studies indicated that a major component involved in the antibody response is X-linked, i.e., carried on the X chromosome; this component determines responsiveness to SSS-III in an almost quantal or "all-or-none" manner. Other factors, presumably autosomal genes, regulate the magnitude of the antibody response produced by mice possessing the X-linked gene; these appear to influence independently the number of antibody-producing cells found after immunization and the amount of antibody made by such cells. Strains of inbred mice varied widely in their ability to respond to SSS-III. Responsiveness was not associated with H-2 histocompatibility type. The implications of these findings with respect to the genetic control of the antibody response to SSS-III are discussed.

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