Resistance of Noradrenaline in Blood Vessels to Depletion by 6-hydroxydopamine or Immunosympathectomy

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1972 Jan 1

PMID 4401306

Citations 14

Authors

B A Berkowitz

S Spector

J H Tarver

Affiliations

Soon will be listed here.

Abstract

1. The degree of the decrease in the noradrenaline concentrations caused by 6-hydroxydopamine or immunosympathectomy was different in different areas of the cardiovascular system.2. In rats or guinea-pigs 6-hydroxydopamine depleted the noradrenaline content of the heart by 90%, of the mesenteric vein by 80% and of the mesenteric artery and aorta by 30-60%. Immunosympathectomy elicited a 70% reduction in the cardiac noradrenaline but only a 50% reduction in the noradrenaline of the blood vessels of the rat.3. The tyrosine hydroxylase activity of the heart, blood vessels, or adrenal glands was not significantly altered 2 weeks after 6-hydroxydopamine. Nor was the monoamine oxidase activity in heart or blood vessels changed.4. The inconsistent ability of both 6-hydroxydopamine and immunosympathectomy to abolish experimental hypertension may be due to the partial persistence of noradrenaline and functional sympathetic nervous system activity in the blood vessels.

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Rapid recovery of vascular adrenergic nerves in the rat after chemical sympathectomy with 6-hydroxydopamine.

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The effects of an anti-atherosclerotic drug, pyridinolcarbamate, on heart, vascular and brain biogenic amines.

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References

Levi-Montalcini R, ANGELETTI P . Second symposium on catecholamines. Modification of sympathetic function. Immunosympathectomy. Pharmacol Rev. 1966; 18(1):619-28. View

Varma D . Antihypertensive effect of methyldopa in metacorticoid immunosympathectomized rats. J Pharm Pharmacol. 1967; 19(1):61-2. DOI: 10.1111/j.2042-7158.1967.tb07998.x. View

de la Lande I, Frewin D, Waterson J . The influence of sympathetic innervation on vascular sensitivity to noradrenaline. Br J Pharmacol Chemother. 1967; 31(1):82-93. PMC: 1557294. DOI: 10.1111/j.1476-5381.1967.tb01979.x. View

Thoenen H, Tranzer J . Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-Hydroxydopamine. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1968; 261(3):271-88. DOI: 10.1007/BF00536990. View

Thoenen H, Mueller R, Axelrod J . Increased tyrosine hydroxylase activity after drug-induced alteration of sympathetic transmission. Nature. 1969; 221(5187):1264. DOI: 10.1038/2211264a0. View

Ceasar P, RUTHVEN C, Sandler M . Catecholamine and 5-hydroxyindole metabolism in immunosympathectomized rats. Br J Pharmacol. 1969; 36(1):70-8. PMC: 1703554. DOI: 10.1111/j.1476-5381.1969.tb08304.x. View

Ong H, Creveling C, Daly J . The synthesis of 2,4,5-trihydroxyphenylalanine (6-hydroxydopa). A centrally active norepinephrine-depleting agent. J Med Chem. 1969; 12(3):458-62. DOI: 10.1021/jm00303a028. View

Thoenen H, Mueller R, Axelrod J . Trans-synaptic induction of adrenal tyrosine hydroxylase. J Pharmacol Exp Ther. 1969; 169(2):249-54. View

BIGELOW L, Dairman W, WEIL-MALHERBE H, UDENFRIEND S . Increased synthesis of catecholamines and their metabolites following the administration of phenoxybenzamine. Mol Pharmacol. 1969; 5(6):565-71. View

10.

Finch L, Leach G . A comparison of the effects of 6-hydroxydopamine immunosympathectomy and reserpine on the cardiovascular reactivity in the rat. J Pharm Pharmacol. 1970; 22(5):354-60. DOI: 10.1111/j.2042-7158.1970.tb08537.x. View

11.

Siggins G, Bloom F . Cytochemical and physiological effects of 6-hydroxydopamine on periarteriolar nerves of frogs. Circ Res. 1970; 27(1):23-38. DOI: 10.1161/01.res.27.1.23. View

12.

Finch L, Leach G . The contribution of the sympathetic nervous system to the development and maintenance of experimental hypertension in the rat. Br J Pharmacol. 1970; 39(2):317-24. PMC: 1702842. DOI: 10.1111/j.1476-5381.1970.tb12895.x. View

13.

Lowe M, Horita A . Stability of cardiac monoamine oxidase activity after chemical sympathectomy with 6-hydroxydopamine. Nature. 1970; 228(5267):175-6. DOI: 10.1038/228175a0. View

14.

Finch L, Leach G . Does the adrenal medulla contribute to the maintenance of experimental hypertension?. Eur J Pharmacol. 1970; 11(3):388-91. DOI: 10.1016/0014-2999(70)90016-6. View

15.

Berkowitz B, Spector S, Brossi A, Focella A, Teitel S . Preparation and biological properties of (-)- and (+)-6-hydroxydopa. Experientia. 1970; 26(9):982-3. DOI: 10.1007/BF02114144. View

16.

Varma D . An assessment of the role of the sympathetic nervous system in experimental hypertension using normal and immunosympathectomized rats. Br J Pharmacol. 1970; 40(2):175-85. PMC: 1702887. DOI: 10.1111/j.1476-5381.1970.tb09911.x. View

17.

de la Lande I, Hill B, Jellett L, Mcneil J . The role of monoamine oxidase in the response of the isolated central artery of the rabbit ear to tyramine. Br J Pharmacol. 1970; 40(2):249-56. PMC: 1702879. DOI: 10.1111/j.1476-5381.1970.tb09918.x. View

18.

Clark D . Effects of immunosympathectomy on development of high blood pressure in genetically hypertensive rats. Circ Res. 1971; 28(3):330-6. DOI: 10.1161/01.res.28.3.330. View

19.

Tarver J, Berkowitz B, Spector S . Alterations in tyrosine hydroxylase and monoamine oxidase activity in blood vessels. Nat New Biol. 1971; 231(25):252-3. DOI: 10.1038/newbio231252a0. View

20.

Berkowitz B, Tarver J, Spector S . Norepinephrine in blood vessels: concentration, binding, uptake and depletion. J Pharmacol Exp Ther. 1971; 177(1):119-26. View