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Effect of Beta-adrenoceptive Blocking Agents on the Response to Bronchoconstrictor Drugs in the Guinea-pig Air Overflow Preparation. Appendix Describing a New Modification of the Air Overflow Method

Overview
Journal Br J Pharmacol
Publisher Wiley
Specialty Pharmacology
Date 1971 Jan 1
PMID 4396128
Citations 16
Authors
D T Burden
M W PARKES
D G Gardiner
Affiliations
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Abstract

1. Propranolol augmented the bronchoconstrictor response to methacholine or histamine, recorded by air overflow in the anaesthetized, vagotomized guinea-pig.2. After adrenalectomy, propranolol was still active, though less so than before.3. In the pithed guinea-pig, there was no augmentation of the effect of bronchoconstrictors on air overflow. The action of propranolol could thus be due to the beta-adrenoceptor blockade of compensatory sympathetic bronchodilator activity, as concluded by McCulloch, Proctor & Rand (1967).4. Electrical stimulation of the thoracic region of the spinal cord of the pithed guinea-pig reduced the effect of bronchoconstrictors on air overflow. This reduction could be blocked by propranolol; practolol was much less effective.

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References
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MacDonald A, INGRAM C, McNeill R . The effect of propranolol on airway resistance. Br J Anaesth. 1967; 39(12):919-26. DOI: 10.1093/bja/39.12.919. View
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McCulloch M, Proctor C, Rand M . Evidence for an adrenergic homeostatic bronchodilator reflex mechanism. Eur J Pharmacol. 1967; 2(3):214-23. DOI: 10.1016/0014-2999(67)90090-8. View