Increased Vascular Permeability Produced by Human Platelet Granule Cationic Extract

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1970 Feb 1

PMID 4391559

Citations 32

Authors

R L Nachman

B Weksler

B Ferris

Affiliations

Soon will be listed here.

Abstract

A cationic protein extract obtained from isolated human platelet granules increased vascular permeability in mouse and rabbit skin. The permeability-enhancing effect was not inhibited by soybean trypsin and pancreatic trypsin inhibitor, methylsergide maleate, carboxypeptidase B, and C[unk]1 inactivator. Permeability-enhancing activity was blocked by prior treatment of challenged animals with antihistamine. The nondializable relatively heat-stable cationic granule protein extract possessed potent mastocytolytic activity. The experiments described suggest that human platelets exert a permeability-enhancing effect by lysosomal release of cationic proteins which cause histamine release from adjacent tissue mast cells.

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