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The Effects of Some Beta-adrenoreceptor Blocking Drugs on the Uptake and Release of Noradrenaline by the Heart

Overview
Journal Br J Pharmacol
Publisher Wiley
Specialty Pharmacology
Date 1968 Sep 1
PMID 4386370
Citations 19
Authors
J W Foo
A Jowett
A Stafford
Affiliations
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Abstract

1. The potencies of some beta-adrenoreceptor blocking drugs in reducing noradrenaline uptake by the isolated heart were compared with their potencies in reducing the release of noradrenaline from the heart by tyramine.2. Of the drugs tested, propranolol, pronethalol and dichloroisoprenaline were the most potent in blocking uptake and release of noradrenaline, although none was at potent as cocaine; MJ 1999 and I.C.I. 50172 were only weakly effective.3. Pronethalol and dichloroisoprenaline each reduced release of noradrenaline by tyramine in the concentration range (10(-7)-10(-6)M) where blockade of responses to tyramine was apparent; with these drugs both reduction of noradrenaline release and beta-receptor blockade contribute to the reduction in responses to tyramine.4. Potency of beta-receptor blocking drugs in reducing noradrenaline uptake is unrelated to potency in blocking beta-receptors; Kö 592 blocks beta-receptors without affecting noradrenaline uptake.

Citing Articles

The noradrenaline rate in the anaesthetized rabbit: facilitation by adrenaline.

Majewski H, HEDLER L, Starke K Naunyn Schmiedebergs Arch Pharmacol. 1982; 321(1):20-7.

PMID: 7144924 DOI: 10.1007/BF00586343.

The inhibition by (+/-)-propranolol of the positive inotropic effects of (+/-)-isoprenaline and (-)-noradrenaline. Competitive antagonism and saturable uptake.

Ebner F Naunyn Schmiedebergs Arch Pharmacol. 1981; 316(2):96-107.

PMID: 6264333 DOI: 10.1007/BF00505301.

The extraneuronal uptake and localization of noradrenaline in the cat spleen and the effect on this of some drugs, of cold and of denervation.

Gillespie J, Hamilton D, Hosie J J Physiol. 1970; 206(3):563-90.

PMID: 5498506 PMC: 1348666. DOI: 10.1113/jphysiol.1970.sp009031.

[Behavior of the ECG in normal, reserpinized or emetinized rats previously perfused with various beta-adrenolytic agents].

MARMO E Arch Kreislaufforsch. 1969; 59(3):325-50.

PMID: 5405509

Pharmacology of AH 5158; a drug which blocks both - and -adrenoceptors.

Farmer J, Kennedy I, Levy G, Marshall R Br J Pharmacol. 1972; 45(4):660-75.

PMID: 4404413 PMC: 1665961. DOI: 10.1111/j.1476-5381.1972.tb08125.x.

References
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