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The Electrostatic Basis of Mg++ Inhibition of Transmitter Release

Overview
Journal Proc Natl Acad Sci U S A
Specialty Science
Date 1974 Mar 1
PMID 4362638
Citations 22
Authors
R U Muller
A Finkelstein
Affiliations
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Abstract

The inhibition by Mg(++) of stimulus-evoked transmitter release is attributed to a decrease in surface potential, Psi(0), on the outer surface of the presynaptic terminal and hence a lower surface calcium concentration, [Ca(++)](0). Data on the frog neuromuscular junction are quantitatively fit by assuming that there is a negative charge density, sigma, on the outer surface of the presynaptic terminal of 6.5 x 10(13) charges per cm(2) and that simple diffuse double layer theory is applicable. No specific binding of Mg(++) or Ca(++) is required. Without any additional assumptions, the inhibitory effect of univalent cations is also quantitatively predicted.

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References
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