Magnesium (Mg): Essential Mineral for Neuronal Health: From Cellular Biochemistry to Cognitive Health and Behavior Regulation

Overview

Journal Curr Pharm Des

Publisher Bentham Science Publishers

Date 2024 Sep 10

PMID 39253923

Authors

Aakash Kumar

Sidharth Mehan

Aarti Tiwari

Zuber Khan

Ghanshyam Das Gupta

Acharan S Narula

Rajaram Samant

Affiliations

Soon will be listed here.

Abstract

Magnesium (Mg) is a crucial mineral involved in numerous cellular processes critical for neuronal health and function. This review explores the multifaceted roles of Mg, from its biochemical interactions at the cellular level to its impact on cognitive health and behavioral regulation. Mg acts as a cofactor for over 300 enzymatic reactions, including those involved in ATP synthesis, nucleic acid stability, and neurotransmitter release. It regulates ion channels, modulates synaptic plasticity, and maintains the structural integrity of cell membranes, which are essential for proper neuronal signaling and synaptic transmission. Recent studies have highlighted the significance of Mg in neuroprotection, showing its ability to attenuate oxidative stress, reduce inflammation, and mitigate excitotoxicity, thereby safeguarding neuronal health. Furthermore, Mg deficiency has been linked to a range of neuropsychiatric disorders, including depression, anxiety, and cognitive decline. Supplementation with Mg, particularly in the form of bioavailable compounds such as Magnesium-L-Threonate (MgLT), Magnesium-Acetyl-Taurate (MgAT), and other Magnesium salts, has shown some promising results in enhancing synaptic density, improving memory function, and alleviating symptoms of mental health disorders. This review highlights significant current findings on the cellular mechanisms by which Mg exerts its neuroprotective effects and evaluates clinical and preclinical evidence supporting its therapeutic potential. By elucidating the comprehensive role of Mg in neuronal health, this review aims to underscore the importance of maintaining optimal Mg levels for cognitive function and behavioral regulation, advocating for further research into Mg supplementation as a viable intervention for neuropsychiatric and neurodegenerative conditions.

References

Bara M, Guiet-Bara A . Potassium, magnesium and membranes. Review of present status and new findings. Magnesium. 1984; 3(4-6):215-25. View

GARFINKEL L, Garfinkel D . Magnesium regulation of the glycolytic pathway and the enzymes involved. Magnesium. 1985; 4(2-3):60-72. View

Seyama T, Kamei Y, Iriyama T, Imada S, Ichinose M, Toshimitsu M . Pretreatment with magnesium sulfate attenuates white matter damage by preventing cell death of developing oligodendrocytes. J Obstet Gynaecol Res. 2018; 44(4):601-607. DOI: 10.1111/jog.13568. View

Stangherlin A, ONeill J . Signal Transduction: Magnesium Manifests as a Second Messenger. Curr Biol. 2018; 28(24):R1403-R1405. DOI: 10.1016/j.cub.2018.11.003. View

Tai Y, Qiu Y, Bao Z . Magnesium Lithospermate B Suppresses Lipopolysaccharide-Induced Neuroinflammation in BV2 Microglial Cells and Attenuates Neurodegeneration in Lipopolysaccharide-Injected Mice. J Mol Neurosci. 2017; 64(1):80-92. DOI: 10.1007/s12031-017-1007-9. View

Poleszak E, Wlaz P, Wrobel A, Fidecka S, Nowak G . NMDA/glutamate mechanism of magnesium-induced anxiolytic-like behavior in mice. Pharmacol Rep. 2008; 60(5):655-63. View

Abiri B, Sarbakhsh P, Vafa M . Randomized study of the effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammation, and SIRT1 in obese women with mild to moderate depressive symptoms. Nutr Neurosci. 2021; 25(10):2123-2135. DOI: 10.1080/1028415X.2021.1945859. View

Hu J, Xu X, Yang J, Wu G, Sun C, Lv Q . Antihypertensive effect of taurine in rat. Adv Exp Med Biol. 2009; 643:75-84. DOI: 10.1007/978-0-387-75681-3_8. View

Wu C, Xue L, Su L, Xie J, Jiang H, Yu X . Magnesium promotes the viability and induces differentiation of neural stem cells both in vitro and in vivo. Neurol Res. 2019; 41(3):208-215. DOI: 10.1080/01616412.2018.1544400. View

10.

Vennemeyer J, Hopkins T, Kuhlmann J, Heineman W, Pixley S . Effects of elevated magnesium and substrate on neuronal numbers and neurite outgrowth of neural stem/progenitor cells in vitro. Neurosci Res. 2014; 84:72-8. DOI: 10.1016/j.neures.2014.05.001. View

11.

Zhu D, Su Y, Fu B, Xu H . Magnesium Reduces Blood-Brain Barrier Permeability and Regulates Amyloid-β Transcytosis. Mol Neurobiol. 2018; 55(9):7118-7131. DOI: 10.1007/s12035-018-0896-0. View

12.

Sun Q, Weinger J, Mao F, Liu G . Regulation of structural and functional synapse density by L-threonate through modulation of intraneuronal magnesium concentration. Neuropharmacology. 2016; 108:426-39. DOI: 10.1016/j.neuropharm.2016.05.006. View

13.

Li W, Yu J, Liu Y, Huang X, Abumaria N, Zhu Y . Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer's disease mouse model. Mol Brain. 2014; 7:65. PMC: 4172865. DOI: 10.1186/s13041-014-0065-y. View

14.

Bush A . Kalzium ist nicht alles. Neuron. 2010; 65(2):143-4. DOI: 10.1016/j.neuron.2010.01.015. View

15.

Slutsky I, Abumaria N, Wu L, Huang C, Zhang L, Li B . Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010; 65(2):165-77. DOI: 10.1016/j.neuron.2009.12.026. View

16.

Xiong W, Liang Y, Li X, Liu G, Wang Z . Erythrocyte intracellular Mg(2+) concentration as an index of recognition and memory. Sci Rep. 2016; 6:26975. PMC: 4890594. DOI: 10.1038/srep26975. View

17.

Campo-Soria C, Chang Y, Weiss D . Mechanism of action of benzodiazepines on GABAA receptors. Br J Pharmacol. 2006; 148(7):984-90. PMC: 1751932. DOI: 10.1038/sj.bjp.0706796. View

18.

Giordano C, Powell H, Leopizzi M, de Curtis M, Travaglini C, Sebastiani M . Fatal congenital myopathy and gastrointestinal pseudo-obstruction due to POLG1 mutations. Neurology. 2009; 72(12):1103-5. PMC: 2821839. DOI: 10.1212/01.wnl.0000345002.47396.e1. View

19.

Yamanaka R, Shindo Y, Oka K . Magnesium Is a Key Player in Neuronal Maturation and Neuropathology. Int J Mol Sci. 2019; 20(14). PMC: 6678825. DOI: 10.3390/ijms20143439. View

20.

Wu L, Mao S, Lin X, Yang R, Zhu Z . Evaluation of Whole Blood Trace Element Levels in Chinese Children with Autism Spectrum Disorder. Biol Trace Elem Res. 2019; 191(2):269-275. DOI: 10.1007/s12011-018-1615-4. View