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The Roles of the Lambda C3 Gene and the Escherichia Coli Catabolite Gene Activation System in the Establishment of Lysogeny by Bacteriophage Lambda

Overview
Journal Proc Natl Acad Sci U S A
Specialty Science
Date 1974 Mar 1
PMID 4362632
Citations 17
Authors
M Belfort
D Wulff
Affiliations
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Abstract

Maximum lysogenization of E. coli by bacteriophage lambda requires both the lambdacIII gene function and the host catabolite gene activation system mediated by adenosine 3':5'-cyclic monophosphate. Whereas considerable lysogenization occurs in the presence of either system alone, lysogenization is absolutely prevented in the absence of both systems. Neither system is, however, required for efficient lysogenization when the host bears an hfl(-) mutation. It is argued that the normal function of these two systems is to negate the antagonistic effect of the Hfl(+) protein upon lysogenization. It is further argued that both the lambdacIII gene function and the Hfl(+) protein do not directly affect the host catabolite gene activation system.

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References
1.
GILMAN A . A protein binding assay for adenosine 3':5'-cyclic monophosphate. Proc Natl Acad Sci U S A. 1970; 67(1):305-12. PMC: 283204. DOI: 10.1073/pnas.67.1.305. View
2.
Reichardt L, Kaiser A . Control of lambda repressor synthesis. Proc Natl Acad Sci U S A. 1971; 68(9):2185-9. PMC: 389381. DOI: 10.1073/pnas.68.9.2185. View
3.
Echols H, Green L . Establishment and maintenance of repression by bacteriophage lambda: the role of the cI, cII, and c3 proteins. Proc Natl Acad Sci U S A. 1971; 68(9):2190-4. PMC: 389382. DOI: 10.1073/pnas.68.9.2190. View
4.
Hong J, Smith G, Ames B . Adenosine 3':5'-cyclic monophosphate concentration in the bacterial host regulates the viral decision between lysogeny and lysis. Proc Natl Acad Sci U S A. 1971; 68(9):2258-62. PMC: 389396. DOI: 10.1073/pnas.68.9.2258. View
5.
Grodzicker T, ARDITTI R, Eisen H . Establishment of repression by lambdoid phage in catabolite activator protein and adenylate cyclase mutants of Escherichia coli. Proc Natl Acad Sci U S A. 1972; 69(2):366-70. PMC: 426459. DOI: 10.1073/pnas.69.2.366. View