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A Depression of Cell-mediated Immunity to Measles Antigen in Patients with Systemic Lupus Erythematosus

Overview
Journal J Exp Med
Specialties Allergy & Immunology
General Medicine
Date 1974 Apr 1
PMID 4361242
Citations 6
Authors
V Utermohlen
J B Winfield
J B Zabriskie
H G KUNKEL
Affiliations
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Abstract

Using the direct migration inhibition test, response to measles antigen in patients with systemic lupus erythematosus (SLE) was found to be decreased when compared with that of normal subjects. No alteration was observed in similar experiments using parainfluenza type 1 and rubella antigens. The specific decrease in measles antigen effect showed no obvious correlation with activity of SLE or with the presence of lymphocytotoxic antibodies. Whether the specificity of the decrease in reactivity is due to some particular relationship between the measles virus or antigen and SLE, or to the possibility that measles reactivity is a more sensitive indicator of a generalized defect of cell-mediated immunity, remains unclear.

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