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Hormonal Control of the Renal Conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol

Overview
Journal J Clin Invest
Specialty General Medicine
Date 1972 Sep 1
PMID 4344734
Citations 54
Authors
H Rasmussen
M Wong
D Bikle
D B GOODMAN
Affiliations
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Abstract

Isolated renal tubules from vitamin D-deficient chicks catalyse the in vitro conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol. This conversion is stimulated by 5 x 10(-10) M bovine parathyroid hormone, or by 10(-6) M cyclic AMP. It is inhibited by 10(-9) M porcine calcitonin. It is concluded that these hormonal controls of the synthesis of the renal hormone 1,25-dihydroxycholecalciferol are of particular physiological significance in coordinating the activities of the various organs involved in extracellular calcium homeostasis.

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