Effect of Prostaglandin E 1 on Certain Renal Actions of Parathyroid Hormone

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1972 Sep 1

PMID 4344730

Citations 9

Authors

N P Beck

F R Derubertis

M F Michelis

R D Fusco

J B Field

B B Davis

Affiliations

Soon will be listed here.

Abstract

Parathyroid hormone increased basal adenyl cyclase activity and that increase was inhibited by prostaglandin E(1) (PGE(1)). Tissue cyclic 3',5'-adenosine monophosphate (cyclic AMP) concentrations were increased by parathyroid hormone and that increase was likewise inhibited by PGE(1). Both parathyroid hormone and dibutyryl cyclic AMP increased (32)P incorporation into renal cortical phospholipids. PGE(1) diminished the effect of parathyroid hormone but not dibutyryl cyclic AMP to influence that parameter. PGE(1) likewise modulated the effect of parathyroid hormone but not dibutyryl cyclic AMP to decrease fractional phosphate reabsorption by the renal tubule. It is suggested that PGE(1) inhibits the effect of parathyroid hormone by decreasing its effect on adenyl cyclase. Such interaction may be important in modulating the intracellular action of parathyroid hormone on kidney cortex.

Citing Articles

Effect of prostaglandin E2 on adenylate cyclase system in human kidney cell cultures: interactions with parathormone and arginine-vasopressin.

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Specific inhibition by prostaglandins E2 and I2 of histamine-stimulated [14C]aminopyrine accumulation and cyclic adenosine monophosphate generation by isolated canine parietal cells.

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Direct inhibitory effect of hypercalcemia on renal actions of parathyroid hormone.

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Effects of acetazolamide on the urinary excretion of cyclic AMP and on the activity of renal adenyl cyclase.

RODRIGUEZ H, Walls J, Yates J, KLAHR S J Clin Invest. 1974; 53(1):122-30.

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Rheumatoid arthritis associated with hypoparathyroidism and Sjögren's syndrome.

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