Effect of Pyrrolnitrin on Electron Transport and Oxidative Phosphorylation in Mitochondria Isolated from Neurospora Crassa

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1972 Nov 1

PMID 4343822

Citations 5

Authors

A M Lambowitz

C W SLAYMAN

Affiliations

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Abstract

Pyrrolnitrin, at low concentrations, uncouples oxidative phosphorylation in Neurospora mitochondria. At higher concentrations, pyrrolnitrin inhibits electron transport both in the flavine region and through cytochrome oxidase.

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References

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Wong D, Airall J . The mode of action of antifungal agents: effect of pyrrolnitrin on mitochondrial electron transport. J Antibiot (Tokyo). 1970; 23(2):55-62. DOI: 10.7164/antibiotics.23.55. View

Wong D, Horng J, GORDEE R . Respiratory chain of a pathogenic fungus, Microsporum gypseum: effect of the antifungal agent pyrrolnitrin. J Bacteriol. 1971; 106(1):168-73. PMC: 248658. DOI: 10.1128/jb.106.1.168-173.1971. View

Lambowitz A, SLAYMAN C, Slayman C, BONNER Jr W . The electron transport components of wild type and poky strains of Neurospora crassa. J Biol Chem. 1972; 247(5):1536-45. View

Lambowitz A, Smith E, SLAYMAN C . Electron transport in Neurospora mitochondria. Studies on wild type and poky. J Biol Chem. 1972; 247(15):4850-8. View