Two Cases of "pancreatic Cholera" with Features of Peptide-secreting Adenomatosis of the Pancreas

Overview

Journal Gut

Specialty Gastroenterology

Date 1970 Mar 1

PMID 4316433

Citations 11

Authors

W Sircus

P W Brunt

R J Walker

W P SMALL

C W FALCONER

C G THOMSON

Affiliations

Soon will be listed here.

Abstract

The clinical data are presented of two women with profound metabolic upset from exceptional water and electrolyte losses in diarrhoea. One had an islet-cell adenoma of the pancreas and the other abnormal islets. Gastric and pancreatic function were abnormal in both, consistent with the subsequent demonstration of a pancreatic and choleretic secretagogue in the tumour tissue and pancreatic and gastric secretagogues in circulating blood (Cleator, Thomson, Sircus, and Coombes, 1970).

Citing Articles

Diffuse, Adult-Onset Nesidioblastosis/Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome (NIPHS): Review of the Literature of a Rare Cause of Hyperinsulinemic Hypoglycemia.

Dieterle M, Husari A, Prozmann S, Wiethoff H, Stenzinger A, Rohrich M Biomedicines. 2023; 11(6).

PMID: 37371827 PMC: 10296556. DOI: 10.3390/biomedicines11061732.

A pathophysiological study of the intestinal manifestations of a vasoactive intestinal peptide, calcitonin, and catecholamine-secreting tumour.

Booth I, Fenton T, Milla P, HARRIES J Gut. 1983; 24(10):954-9.

PMID: 6618274 PMC: 1420159. DOI: 10.1136/gut.24.10.954.

[Immunhistologic, cytochemical, and electron-microscopic investigations in Verner-Morrison syndrome (WDHA-syndrome, pancreatic cholera) (author's transl)].

Burkhardt A, MITSCHKE H Virchows Arch A Pathol Anat Histol. 1974; 364(2):145-63.

PMID: 4371730 DOI: 10.1007/BF01240380.

[Carcinoidsyndrome due to anaplastic carcinoma of the pancreas (author's transl)].

LOEWE U, HOER P Klin Wochenschr. 1974; 52(6):283-7.

PMID: 4369501 DOI: 10.1007/BF01468459.

Studies on the potential role of secretin in the islet cell tumor diarrheogenic syndrome.

Sanzenbacher L, Mekhjian H, King D, ZOLLINGER R Ann Surg. 1972; 176(3):394-402.

PMID: 4342161 PMC: 1355414. DOI: 10.1097/00000658-197209000-00015.

References

Jesseph J, MOORE F, ENDAHL G, PASSI R . Peptic ulceration and enteritis. A differential diagnosis. Am J Surg. 1967; 113(2):188-93. DOI: 10.1016/0002-9610(67)90220-6. View

Marks I, Bank S, Louw J . Islet cell tumor of the pancreas with reversible watery diarrhea and achylorhydraia. Gastroenterology. 1967; 52(4):695-708. View

GREENLEE H, LONGHI E, GUERRERO J, Nelsen T, EL-BEDRI A, DRAGSTEDT L . Inhibitory effect of pancreatic secretin on gastric secretion. Am J Physiol. 1957; 190(3):396-402. DOI: 10.1152/ajplegacy.1957.190.3.396. View

Sircus W . Peptide-secreting tumours with special reference to the pancreas. Gut. 1969; 10(7):506-15. PMC: 1552945. DOI: 10.1136/gut.10.7.506. View

Levin M . Endocrine syndromes associated with pancreatic islet cell tumors. Med Clin North Am. 1968; 52(2):295-312. View

ZOLLINGER R, ELLISON E . Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. Ann Surg. 1955; 142(4):709-23; discussion, 724-8. PMC: 1465210. View

Paloyan D, PALOYAN E, WOROBEC R, Ernst K, Deininger E, Harper P . Serum glucagon levels in experimental acute pancreatitis in the dog. Surg Forum. 1966; 17:348-9. View

Shimoda S, Saunders D, RUBIN C . The Zollinger-Ellison syndrome with steatorrhea. II. The mechanism of fat and vitamin B 12 malabsorption. Gastroenterology. 1968; 55(6):705-23. View

GROSSMAN M . Treatment of duodenal ulcer with secretin: a speculative proposal. Gastroenterology. 1966; 50(6):912-3. View

10.

Sircus W . Peptide-seceting adenomata with special reference to the Zollinger-Ellison syndrome. Postgrad Med J. 1968; 44(515):742-8. PMC: 2466682. DOI: 10.1136/pgmj.44.515.742. View

11.

SINGLETON J, KERN Jr F, Waddell W . DIARRHEA AND PANCREATIC ISLET CELL TUMOR: REPORT OF A CASE WITH A SEVERE JEJUNAL MUCOSAL LESION. Gastroenterology. 1965; 49:197-208. View

12.

GOULON M, Rapin M, CHARLEUX H, BAGUET J, KUNTZIGER H, NOUAILHAT F . [Watery diarrhea and hypokalemia associated with a non-insulin-secreting islet cell tumor. Apropos of a case with immediate and definitive cure of the diarrhea by tumoral excision. Nosologic discussion of this syndrome and Zollinger-Ellison syndrome]. Bull Mem Soc Med Hop Paris. 1966; 117(7):623-46. View

13.

James A . GASTRIC EPITHELIUM IN THE DUODENUM. Gut. 1964; 5:285-94. PMC: 1413465. DOI: 10.1136/gut.5.4.285. View

14.

Mansbach 2nd C, Wilkins R, Dobbins W, TYOR M . Intestinal mucosal function and structure in the steatorrhea of Zollinger-Ellison syndrome. Arch Intern Med. 1968; 121(6):487-94. View

15.

Creamer B . VARIATIONS IN SMALL-INTESTINAL VILLOUS SHAPE AND MUCOSAL DYNAMICS. Br Med J. 1964; 2(5421):1371-3. PMC: 1817301. DOI: 10.1136/bmj.2.5421.1371. View

16.

PRIEST W, Alexander M . Isletcell tumour of the pancreas with peptic ulceration, diarrhoea, and hypokalaemia. Lancet. 1957; 273(7006):1145-7. DOI: 10.1016/s0140-6736(57)92051-2. View

17.

Sircus W . PROLONGED AUGMENTATION OF THE MAXIMAL SECRETORY RESPONSES OF CANINE GASTRIC POUCHES BY CHRONIC OBSTRUCTION: A PRELIMINARY REPORT AND A HYPOTHESIS. Am J Dig Dis. 1965; 10:499-505. DOI: 10.1007/BF02233042. View

18.

Gardner J, Cerda J . In vitro inhibition of intestinal fluid and electrolyte transfer by a non-beta islet cell tumor. Proc Soc Exp Biol Med. 1966; 123(2):361-4. DOI: 10.3181/00379727-123-31488. View

19.

Sircus W, Brunt P, Walker R, SMALL W, FALCONER C, THOMSON C . Two cases of "pancreatic cholera" with features of peptide-secreting adenomatosis of the pancreas. Gut. 1970; 11(3):197-205. PMC: 1411440. DOI: 10.1136/gut.11.3.197. View

20.

HINDLE W, McBrien D, Creamer B . WATERY DIARRHOEA AND AN ISLET CELL TUMOUR. Gut. 1964; 5:359-62. PMC: 1413454. DOI: 10.1136/gut.5.4.359. View