» Articles » PMID: 4305077

Glucagon-sensitive Adenyl Cylase in Plasma Membrane of Hepatic Parenchymal Cells

Overview
Journal Science
Specialty Science
Date 1969 May 2
PMID 4305077
Citations 22
Authors
Affiliations
Soon will be listed here.
Abstract

The plasma membrane of hepatic parenchymal cells contains an adenyl cyclase system that is stimulated by glucagon. Adrenocorticotropin and epinephrine do not stimulate this adenyl cyclase, and very little cyclic phospho-diesterase activity is present in the membrane. These findings support the concept that glucagon exerts its regulatory action in the liver by stimulating adenyl cyclase activity in the plasma membrane.

Citing Articles

Bicarbonate, carbon dioxide and pH sensing via mammalian bicarbonate-regulated soluble adenylyl cyclase.

Rossetti T, Jackvony S, Buck J, Levin L Interface Focus. 2021; 11(2):20200034.

PMID: 33633833 PMC: 7898154. DOI: 10.1098/rsfs.2020.0034.


A glucagon analog chemically stabilized for immediate treatment of life-threatening hypoglycemia.

Chabenne J, Chabenne M, Zhao Y, Levy J, Smiley D, Gelfanov V Mol Metab. 2014; 3(3):293-300.

PMID: 24749059 PMC: 3986664. DOI: 10.1016/j.molmet.2014.01.006.


The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors.

Alexander S, Benson H, Faccenda E, Pawson A, Sharman J, Spedding M Br J Pharmacol. 2014; 170(8):1459-581.

PMID: 24517644 PMC: 3892287. DOI: 10.1111/bph.12445.


Minireview: Glucagon in stress and energy homeostasis.

Jones B, Tan T, Bloom S Endocrinology. 2012; 153(3):1049-54.

PMID: 22294753 PMC: 3281544. DOI: 10.1210/en.2011-1979.


Optimization of the native glucagon sequence for medicinal purposes.

Chabenne J, DiMarchi M, Gelfanov V, DiMarchi R J Diabetes Sci Technol. 2010; 4(6):1322-31.

PMID: 21129326 PMC: 3005041. DOI: 10.1177/193229681000400605.