Studies on Cellular Autophagocytosis. Cyclic AMP- and Dibutyryl Cyclic AMP-stimulated Autophagy in Rat Liver

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1973 Sep 1

PMID 4125701

Citations 17

Authors

J D Shelburne

A U ARSTILA

B F Trump

Affiliations

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Abstract

Intraperitoneal injections of either cyclic AMP or dibutyryl cyclic AMP are capable of producing a wave of autophagy in rat liver which resembles closely that stimulated by glucagon. These autophagic vacuoles are acid-phosphatase-positive and appear to arise via the envelopment of organelles by double-walled cisterna. At later times these autophagic vacuoles are usually surrounded by a single membrane. Injection of equimolar amounts of 5'-AMP failed to produce a wave of autophagy. These findings constitute preliminary evidence that glucagon-stimulated autophagy is mediated at least in part by cyclic AMP.

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References

Ericsson J, Trump B . Observations on the application to electron microscopy on the lead phosphate technique for the demonstration of acid phosphatase. Histochemie. 1965; 4(6):470-87. DOI: 10.1007/BF00281900. View

ASHFORD T, PORTER K . Cytoplasmic components in hepatic cell lysosomes. J Cell Biol. 1962; 12:198-202. PMC: 2106008. DOI: 10.1083/jcb.12.1.198. View

Deter R, DE DUVE C . Influence of glucagon, an inducer of cellular autophagy, on some physical properties of rat liver lysosomes. J Cell Biol. 1967; 33(2):437-49. PMC: 2108350. DOI: 10.1083/jcb.33.2.437. View

Deter R, Baudhuin P, DE DUVE C . Participation of lysosomes in cellular autophagy induced in rat liver by glucagon. J Cell Biol. 1967; 35(2):C11-6. PMC: 2107130. DOI: 10.1083/jcb.35.2.c11. View

Schofield B, Crossman I . Electron microscopy of hepatic cell lesions induced by electrocution. Arch Pathol. 1968; 86(2):208-13. View

ARSTILA A, Trump B . Studies on cellular autophagocytosis. The formation of autophagic vacuoles in the liver after glucagon administration. Am J Pathol. 1968; 53(5):687-733. PMC: 2013521. View

POHL S, Birnbaumer L, Rodbell M . Glucagon-sensitive adenyl cylase in plasma membrane of hepatic parenchymal cells. Science. 1969; 164(3879):566-7. DOI: 10.1126/science.164.3879.566. View

EXTON J, Park C . The role of cyclic AMP in the control of liver metabolism. Adv Enzyme Regul. 1968; 6:391-407. DOI: 10.1016/0065-2571(68)90024-1. View

Menahan L, Wieland O . Interactions of glucagon and insulin on the metabolism of perfused livers from fasted rats. Eur J Biochem. 1969; 9(1):55-62. DOI: 10.1111/j.1432-1033.1969.tb00575.x. View

10.

Butcher R, Robison G, Hardman J, SUTHERLAND E . The role of cyclic AMP in hormone actions. Adv Enzyme Regul. 1968; 6:357-89. DOI: 10.1016/0065-2571(68)90023-x. View

11.

Lawrence A . Glucagon. Annu Rev Med. 1969; 20:207-22. DOI: 10.1146/annurev.me.20.020169.001231. View

12.

Levine R, Lewis S, SHULMAN J, Washington A . Metabolism of cyclic adenosine 3',5'-monophosphate-8-14C by isolated, perfused rat liver. J Biol Chem. 1969; 244(15):4017-22. View

13.

Mallet L, EXTON J, Park C . Control of gluconeogenesis from amino acids in the perfused rat liver. J Biol Chem. 1969; 244(20):5713-23. View

14.

Pfeifer U . [Cellular autophagy: glycogen segregation in early stages of a partial liver atrophy]. Virchows Arch B Cell Pathol. 1970; 5(3):242-53. View

15.

Chambers J, Georg R, Bass A . Effect of glucagon, cyclic 3',5'-adenosine monophosphate and its dibutyryl derivative on amino acid uptake by the isolated perfused rat liver. Endocrinology. 1970; 87(2):366-70. DOI: 10.1210/endo-87-2-366. View

16.

TEWS J, Woodcock N, HARPER A . Stimulation of amino acid transport in rat liver slices by epinephrine, glucagon, and adenosine 3',5'-monophosphate. J Biol Chem. 1970; 245(11):3026-32. View

17.

EXTON J, Mallette L, Jefferson L, Wong E, Friedmann N, Park C . Role of adenosine 3',5'-monophosphate in the control of gluconeogenesis. Am J Clin Nutr. 1970; 23(7):993-1003. DOI: 10.1093/ajcn/23.7.993. View

18.

Swislocki N . Decomposition of dibutyryl cyclic AMP in aqueous buffers. Anal Biochem. 1970; 38(1):260-9. DOI: 10.1016/0003-2697(70)90175-2. View

19.

Scott D, Reynolds R, Pitot H, POTTER V . Co-induction of the hepatic amino acid transport system and tyrosine aminotransferase by theophylline, glucagon and dibutyryl-cyclic AMP in vivo. Life Sci II. 1970; 9(19):1133-40. DOI: 10.1016/0024-3205(70)90265-1. View

20.

SUTHERLAND E . On the biological role of cyclic AMP. JAMA. 1970; 214(7):1281-8. View