Effect of Mycoplasma on Interferon Production and Interferon Assay in Cell Cultures

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1966 Jul 1

PMID 4287405

Citations 9

Authors

D Armstrong

K Paucker

Affiliations

Soon will be listed here.

Abstract

Armstrong, D. (The Children's Hospital of Philadelphia, Philadelphia, Pa.), and K. Paucker. Effect of mycoplasma on interferon production and interferon assay in cell cultures. J. Bacteriol. 92:97-101. 1966.-The influence of mycoplasma on the production and action of interferon was studied in cultures of both L and human embryonic kidney (HEK) cells. Mycoplasma hominis 1, the Negroni agent, and the F12 mycoplasma were used for infection of L cells, and M. hominis 1 and M. pneumoniae for inoculation of HEK cells. All strains were capable of multiplication in the culture systems employed. None produced detectable levels of interferon, and responsiveness of the cells to induction of interferon by virus remained unaltered. Infection with mycoplasma did not impair the sensitivity of the cells to the action of interferon, nor was the replication of vesicular stomatitis virus noticeably diminished.

Citing Articles

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Inhibition of growth of measles virus by mycoplasma in cell-cultures and the restoring effect of arginine.

Romano N, Brancato P Arch Gesamte Virusforsch. 1970; 29(1):39-43.

PMID: 4989119 DOI: 10.1007/BF01253878.

Mycoplasmas and cell cultures.

Stanbridge E Bacteriol Rev. 1971; 35(2):206-27.

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Mycoplasma interactions with cell cultures, uncultured living cells and the problems posed by their presence in tissue cultures.

Sethi K, Teschner M Klin Wochenschr. 1972; 50(5):226-33.

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Induction of interferon in mice by mycoplasmas.

Rinaldo Jr C, Cole B, Overall Jr J, Glasgow L Infect Immun. 1974; 10(6):1296-301.

PMID: 4373395 PMC: 423102. DOI: 10.1128/iai.10.6.1296-1301.1974.

References

Somerson N, COOK M . SUPPRESSION OF ROUS SARCOMA VIRUS GROWTH IN TISSUE CULTURES BY MYCOPLASMA ORALE. J Bacteriol. 1965; 90:534-40. PMC: 315675. DOI: 10.1128/jb.90.2.534-540.1965. View

Prince A . Quantitative studies on Rous sarcoma virus. VI. Clonal analysis of in vitro infections. Virology. 1960; 11:400-24. DOI: 10.1016/0042-6822(60)90083-0. View

Negroni G . ISOLATION OF VIRUSES FROM LEUKAEMIC PATIENTS. Br Med J. 1964; 1(5388):927-9. PMC: 1814161. DOI: 10.1136/bmj.1.5388.927. View

Butler M, Leach R . A MYCOPLASMA WHICH INDUCES ACIDITY AND CYTOPATHIC EFFECT IN TISSUE CULTURE. J Gen Microbiol. 1964; 34:285-94. DOI: 10.1099/00221287-34-2-285. View

Paucker K, Cantell K, Henle W . Quantitative studies on viral interference in suspended L cells. III. Effect of interfering viruses and interferon on the growth rate of cells. Virology. 1962; 17:324-34. DOI: 10.1016/0042-6822(62)90123-x. View

Girardi A, Hayflick L, Lewis A, Somerson N . RECOVERY OF MYCOPLASMAS IN THE STUDY OF HUMAN LEUKAEMIA AND OTHER MALIGNANCIES. Nature. 1965; 205:188-9. DOI: 10.1038/205188a0. View

Grist N, MATTHEW H . ISOLATION OF VIRUSES FROM LEUKAEMIC PATIENTS. Br Med J. 1964; 2(5419):1263-4. PMC: 1817202. DOI: 10.1136/bmj.2.5419.1263. View

Yershov F, Zhdanov V . Influence of PPLO on production of interferon in virus-infected cells. Virology. 1965; 27(3):451-3. DOI: 10.1016/0042-6822(65)90132-7. View

Glasgow L . INTERFERON: A REVIEW. J Pediatr. 1965; 67:104-12. DOI: 10.1016/s0022-3476(65)80311-0. View

10.

Cantell K, Paucker K . Studies on viral interference in two lines of HeLa cells. Virology. 1963; 19:81-7. DOI: 10.1016/0042-6822(63)90027-8. View

11.

Armstrong D, Henle G, Somerson N, Hayflick L . CYTOPATHOGENIC MYCOPLASMAS ASSOCIATED WITH TWO HUMAN TUMORS. I. ISOLATION AND BIOLOGICAL ASPECTS. J Bacteriol. 1965; 90:418-24. PMC: 315660. DOI: 10.1128/jb.90.2.418-424.1965. View

12.

Hayflick L . Tissue cultures and mycoplasmas. Tex Rep Biol Med. 1965; 23:Suppl 1:285+. View

13.

Fallon R, Grist N, Inman D, Lemcke R, Negroni G, Woods D . Further studies of agents isolated from tissue cultures inoculated with human leukaemic bone-marrow. Br Med J. 2010; 2(5458):388-91. PMC: 1845428. View

14.

Rubin H . The suppression of morphological alterations in cells infected with Rous sarcoma virus. Virology. 1960; 12:14-31. DOI: 10.1016/0042-6822(60)90146-x. View