Mycoplasma-mediated Hyporeactivity to Various Interferon Inducers

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1975 Dec 11

PMID 1205616

Citations 3

Authors

B C Cole

J C Overall Jr

P S Lombardi

L A Glasgow

Affiliations

Soon will be listed here.

Abstract

Three strains of Mycoplasma arthritidis were shown to induce marked hyporeactivity in mice to interferon induction by both Newcastle disease virus and poly(I:C). In contrast, the interferon response of mice to tilorone was only partially suppressed by pretreatment of the animals with mycoplasms. Hyporeactivity to Newcastle disease virus was maximal 1 and 3 days after mycoplasms treatment, but the interferon response was maximal 1 day after injection of the mycoplasmas and was no longer apparent by 5 days. No relationship was found between the ability of the mycoplasms themselves to induce interferon and the degree of hyporeactivity produced. These results suggest that mycoplasmas may alter virus-host relationships in vivo.

Citing Articles

I-E/I-C region-associated induction of murine gamma interferon by a haplotype-restricted polyclonal T-cell mitogen derived from Mycoplasma arthritidis.

Cole B, Thorpe R Infect Immun. 1984; 43(1):302-7.

PMID: 6418659 PMC: 263426. DOI: 10.1128/iai.43.1.302-307.1984.

Immunosuppressive properties of the Mycoplasma arthritidis T-cell mitogen in vivo: inhibition of proliferative responses to T-cell mitogens.

Cole B, Wells D Infect Immun. 1990; 58(1):228-36.

PMID: 1967168 PMC: 258434. DOI: 10.1128/iai.58.1.228-236.1990.

Induction of interferon in ovine and human lymphocyte cultures by mycoplasmas.

Cole B, Overall Jr J, Lombardi P, Glasgow L Infect Immun. 1976; 14(1):88-94.

PMID: 985808 PMC: 420848. DOI: 10.1128/iai.14.1.88-94.1976.

References

Borden E, Prochownik E, CARTER W . The interferon refractory state. II. Biological characterization of a refractoriness-inducing protein. J Immunol. 1975; 114(2 pt 2):752-6. View

Golightly-Rowland L, Cole B, WARD J, Wiley B . Effect of Animal Passage on Arthritogenic and Biological Properties of Mycoplasma arthritidis. Infect Immun. 1970; 1(6):538-45. PMC: 415939. DOI: 10.1128/iai.1.6.538-545.1970. View

Osborn J, MEDEARIS Jr D . Suppression of interferon and antibody and multiplication of Newcastle disease virus in cytomegalovirus infected mice. Proc Soc Exp Biol Med. 1967; 124(2):347-53. DOI: 10.3181/00379727-124-31740. View

Kasza L, Hodges R, BETTS A, TREXLER P . Pneumonia in gnotobiotic pigs produced by simultaneous inoculation of a swine adenovirus and mycoplasma hyopneumoniae. Vet Rec. 1969; 84(11):262-7. DOI: 10.1136/vr.84.11.262. View

RANCK Jr F, Grumbles L, HALL C, GRIMES J . Serology and gross lesions of turkeys inoculated with an avian influenza A virus, a paramyxovirus, and Mycoplasma gallisepticum. Avian Dis. 1970; 14(1):54-65. View

De Maeyer-Guignard J . Mouse leukemia: depression of serum interferon production. Science. 1972; 177(4051):797-9. DOI: 10.1126/science.177.4051.797. View

Rinaldo Jr C, Overall Jr J, Cole B, Glasgow L . Mycoplasma-associated induction of interferon in ovine leukocytes. Infect Immun. 1973; 8(5):796-803. PMC: 422930. DOI: 10.1128/iai.8.5.796-803.1973. View

MORGUNOVA T, POSTNIKOVA Z, Rakovskaia I, KAGAN G . [Mixed infection of mice of line BAL/B/CDE with Rauscher virus and Mycoplasma laidlawii]. Vopr Virusol. 1974; (2):144-8. View

Rinaldo Jr C, Cole B, Overall Jr J, WARD J, Glasgow L . Induction of interferon in ovine leukocytes by species of mycoplasma and acholeplasma. Proc Soc Exp Biol Med. 1974; 146(2):613-8. DOI: 10.3181/00379727-146-38158. View

10.

Stringfellow D, Glasgow L . Tilorone hydrochloride: an oral interferon-inducing agent. Antimicrob Agents Chemother. 1972; 2(2):73-8. PMC: 444270. DOI: 10.1128/AAC.2.2.73. View

11.

Cole B, WARD J, Martin C . Hemolysin and peroxide activity of Mycoplasma species. J Bacteriol. 1968; 95(6):2022-30. PMC: 315129. DOI: 10.1128/jb.95.6.2022-2030.1968. View

12.

Youngner J, Stinebring W . Interferon appearance stimulated by endotoxin, bacteria, or viruses in mice pre-treated with Escherichia coli endotoxin or infected with Mycobacterium tuberculosis. Nature. 1965; 208(5009):456-8. DOI: 10.1038/208456a0. View

13.

HOLTERMANN O, Havell E . Reduced interferon response in mice congenitally infected with lymphocytic choriomeningitis virus. J Gen Virol. 1970; 9(1):101-3. DOI: 10.1099/0022-1317-9-1-101. View

14.

Buckler C, DUBUY H, Johnson M, Baron S . Kinetics of serum interferon response in mice after single and multiple injections of polyI-poly C. Proc Soc Exp Biol Med. 1971; 136(2):394-8. DOI: 10.3181/00379727-136-35272. View

15.

Hayflick L . Tissue cultures and mycoplasmas. Tex Rep Biol Med. 1965; 23:Suppl 1:285+. View

16.

Chanock R, Hayflick L, Barile M . Growth on artificial medium of an agent associated with atypical pneumonia and its identification as a PPLO. Proc Natl Acad Sci U S A. 1962; 48:41-9. PMC: 285494. DOI: 10.1073/pnas.48.1.41. View

17.

Vilcek J, Rada B . Studies on an interferon from tickborne encephalitis virus-infected cells (IF). III. Antiviral action of IF. Acta Virol. 1962; 6:9-16. View

18.

Stringfellow D . Hyporeactivity to interferon induction: characterization of a hyporeactive factor in the serum of encephalomyocarditis virus-infected mice. Infect Immun. 1975; 11(2):294-302. PMC: 415060. DOI: 10.1128/iai.11.2.294-302.1975. View

19.

Murphy B, Glasgow L . Factors modifying host resistance to viral infection. 3. Effect of whole body x-irradiation on experimental encephalomyocarditis virus infection in mice. J Exp Med. 1968; 127(5):1035-52. PMC: 2138485. DOI: 10.1084/jem.127.5.1035. View

20.

Singer S, Barile M, KIRSCHSTEIN R . Enhanced virus yields and decreased interferon production in mycoplasma-infected hamster cells. Proc Soc Exp Biol Med. 1969; 131(4):1129-34. DOI: 10.3181/00379727-131-34053. View