Lack of Copulatory Behaviour in Male Castrated Rats After P-chlorophenylalanine

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1974 Jun 1

PMID 4281334

Citations 1

Authors

M Del Fiacco

W Fratta

G L Gessa

A Tagliamonte

Affiliations

Soon will be listed here.

Abstract

1 The effect of p-chlorophenylalanine (PCPA) on the copulatory behaviour of normal and castrated male rats with females in oestrus was studied.2 Castration 2 months before the experiment completely prevented the increased copulatory behaviour produced by PCPA in normal rats.3 The administration of testosterone restored the copulatory behaviour in the castrated rats indicating that testosterone is essential for this behaviour.

Citing Articles

Serotonergic modulation of male-like pseudocopulatory behavior in the parthenogenetic whiptail lizard, Cnemidophorus uniparens.

Dias B, Crews D Horm Behav. 2006; 50(3):401-9.

PMID: 16793042 PMC: 2394198. DOI: 10.1016/j.yhbeh.2006.05.001.

References

KOE B, Weissman A . p-Chlorophenylalanine: a specific depletor of brain serotonin. J Pharmacol Exp Ther. 1966; 154(3):499-516. View

Lindstrom L, Meyerson B . The effect of pilocarpine, oxotremorine and arecoline in combination with methyl-atropine or atropine on hormone activated oestrous behaviour in ovariectomized rats. Psychopharmacologia. 1967; 11(5):405-13. DOI: 10.1007/BF00405024. View

Sheard M . The effect of p-chlorophenylalanine on behavior in rats: relation to brain serotonin and 5-hydroxyindoleacetic acid. Brain Res. 1969; 15(2):524-8. DOI: 10.1016/0006-8993(69)90175-9. View

Tagliamonte A, Tagliamonte P, Gessa G, Brodie B . Compulsive sexual activity induced by p-chlorophenylalanine in normal and pinealectomized male rats. Science. 1969; 166(3911):1433-5. DOI: 10.1126/science.166.3911.1433. View

Shillito E . The effect of parachlorophenylalanine on social interaction of male rats. Br J Pharmacol. 1970; 38(2):305-15. PMC: 1702805. DOI: 10.1111/j.1476-5381.1970.tb08518.x. View

Ferguson J, Henriksen S, Cohen H, Mitchell G, Barchas J, Dement W . "Hypersexuality" and behavioral changes in cats caused by administration of p-chlorophenylalanine. Science. 1970; 168(3930):499-501. DOI: 10.1126/science.168.3930.499. View

Gessa G, Tagliamonte A, Brodie B . Essential role of testosterone in the sexual stimulation induced by p-chlorophenylalanine in male animals. Nature. 1970; 227(5258):616-7. DOI: 10.1038/227616a0. View

Hoyland V, Shillito E, Vogt M . The effect of parachlorophenylalanine on the behaviour of cats. Br J Pharmacol. 1970; 40(4):659-67. PMC: 1702927. DOI: 10.1111/j.1476-5381.1970.tb10645.x. View

Gessa G, Tagliamonte A, Tagliamonte P . Aphrodisiac effect of p-chlorophenylalanine. Science. 1971; 171(3972):706. DOI: 10.1126/science.171.3972.706. View

10.

Tagliamonte A, Tagliamonte P, Gessa G . Reversal of pargyline-induced inhibition of sexual behaviour in male rats by p-chlorophenylalanine. Nature. 1971; 230(5291):244-5. DOI: 10.1038/230244a0. View

11.

PEREZ-CRUET J, Tagliamonte A, Tagliamonte P, Gessa G . Stimulation of serotonin synthesis by lithium. J Pharmacol Exp Ther. 1971; 178(2):325-30. View

12.

Malmnas C, Meyerson B . p-chlorophenylalanine and copulatory behaviour in the male rat. Nature. 1971; 232(5310):398-400. DOI: 10.1038/232398a0. View

13.

Gawienowski A, Hodgen G . Homosexual activity in male rats after p-chlorophenylalanine: effects of hypophysectomy and testosterone. Physiol Behav. 1971; 7(4):551-5. DOI: 10.1016/0031-9384(71)90108-9. View

14.

Bond V, Shillito E, Vogt M . Influence of age and of testosterone on the response of male rats to parachlorophenylalanine. Br J Pharmacol. 1972; 46(1):46-55. PMC: 1666122. DOI: 10.1111/j.1476-5381.1972.tb06847.x. View