Compulsive Gnawing in Rats After Implantation of Drugs into the Ventral Thalamus. A Contribution to the Mechanism of Morphine Action

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1974 Jun 1

PMID 4281333

Citations 6

Authors

F Bergmann

M CHAIMOVITZ

V Pasternak

A Ramu

Affiliations

Soon will be listed here.

Abstract

1 Implantation of morphine into various parts of the corpus striatum of rats evokes only weak gnawing responses.2 Deposition of apomorphine, morphine or methadone in the region of the nucleus ventralis thalami produces a biphasic response, i.e. general excitation, followed by a period of intense gnawing.3 The effect of both apomorphine and morphine is blocked by chlorpromazine, haloperidol and pimozide. However, pretreatment with alpha-methyltyrosine methyl ester or alpha-methyldopa prevents only the gnawing response to morphine, but not to apomorphine.4 Systemic nalorphine, morphine or pethidine suppress the gnawing response, evoked by thalamic implants of apomorphine or morphine.5 Systemic amphetamine potentiates the effect of thalamic deposits of morphine.6 Compulsive gnawing, following implantation of morphine into the ventral region of the thalamus, probably results from enhanced production and release of catecholamines.

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References

ERNST A . Relation between the action of dopamine and apomorphine and their O-methylated derivatives upon the CNS. Psychopharmacologia. 1965; 7(6):391-9. DOI: 10.1007/BF00402361. View

Smelik P, ERNST A . Role of nigro-neostriatal dopaminergic fibers in compulsive gnawing behavior in rats. Life Sci. 1966; 5(16):1485-8. DOI: 10.1016/0024-3205(66)90222-0. View

CORRODI H, Hanson L . Central effects of an inhibitor of tyrosine hydroxylation. Psychopharmacologia. 1966; 10(2):116-25. DOI: 10.1007/BF00455973. View

TENEN S . Antagonism of the analgesic effect of morphine and other drugs by p-chlorophenylalanine, a serotonin depletor. Psychopharmacologia. 1968; 12(4):278-85. DOI: 10.1007/BF00401407. View

Janssen P, NIEMEGEERS C, SCHELLEKENS K, Dresse A, Lenaerts F, PINCHARD A . Pimozide, a chemically novel, highly potent and orally long-acting neuroleptic drug. I. The comparative pharmacology of pimozide, haloperidol, and chlorpromazine. Arzneimittelforschung. 1968; 18(3):261-79. View

Carlsson A, Lindqvist M . Central and peripheral monoaminergic membrane-pump blockade by some addictive analgesics and antihistamines. J Pharm Pharmacol. 1969; 21(7):460-4. DOI: 10.1111/j.2042-7158.1969.tb08287.x. View

Fog R . Behavioural effects in rats of morphine and amphetamine and of a combination of the two drugs. Psychopharmacologia. 1970; 16(4):305-12. DOI: 10.1007/BF00404736. View

CLOUET D, Ratner M . Catecholamine biosynthesis in brains of rats treated with morphine. Science. 1970; 168(3933):854-6. DOI: 10.1126/science.168.3933.854. View

ANDEN N, Butcher S, CORRODI H, Fuxe K, Ungerstedt U . Receptor activity and turnover of dopamine and noradrenaline after neuroleptics. Eur J Pharmacol. 1970; 11(3):303-14. DOI: 10.1016/0014-2999(70)90006-3. View

10.

PENN R, Rogers K . Comparison of the effects of morphine, pethidine and pentazocine in rabbits pretreated with a monoamine oxidase inhibitor. Br J Pharmacol. 1971; 42(3):485-92. PMC: 1665663. DOI: 10.1111/j.1476-5381.1971.tb07133.x. View

11.

MENGE H, Brand U . [Stereotypy following amphetamine and apomorphine and its influencing by drugs]. Psychopharmacologia. 1971; 21(3):212-28. DOI: 10.1007/BF00403860. View

12.

Major C, Pleuvry B . Effects of alpha-methyl-p-tyrosine, p-chlorophenylalanine, l-beta-(3,4-dihydroxyphenyl)alanine, 5-hydroxytryptophan and diethyldithiocarbamate on the analgesic activity of morphine and methylamphetamine in the mouse. Br J Pharmacol. 1971; 42(4):512-21. PMC: 1665735. DOI: 10.1111/j.1476-5381.1971.tb07137.x. View

13.

Pinder R, Buxton D, Green D . On the dopamine-like action of apomorphine. J Pharm Pharmacol. 1971; 23(12):995-6. DOI: 10.1111/j.2042-7158.1971.tb09919.x. View

14.

SASAME H, PEREZ-CRUET J, Di Chiara G, Tagliamonte A, Tagliamonte P, Gessa G . Evidence that methadone blocks dopamine receptors in the brain. J Neurochem. 1972; 19(8):1953-7. DOI: 10.1111/j.1471-4159.1972.tb01484.x. View

15.

Kuschinsky K, Hornykiewicz O . Morphine catalepsy in the rat: relation to striatal dopamine metabolism. Eur J Pharmacol. 1972; 19(1):119-22. DOI: 10.1016/0014-2999(72)90086-6. View

16.

Fukui K, Shiomi H, Takagi H . Effect of morphine on tyrosine hydroxylase activity in mouse brain. Eur J Pharmacol. 1972; 19(1):123-5. DOI: 10.1016/0014-2999(72)90087-8. View

17.

Ayhan I, RANDRUP A . Role of brain noradrenaline in morphine-induced stereotyped behaviour. Psychopharmacologia. 1972; 27(3):203-12. DOI: 10.1007/BF00422800. View

18.

Wolfarth S, Grabowska M, Lacki M, Dulska E, Antkiewicz L . The action of apomorphine in rats with striatal lesions. Act Nerv Super (Praha). 1973; 15(2):132-3. View

19.

Fuxe K . EVIDENCE FOR THE EXISTENCE OF MONOAMINE NEURONS IN THE CENTRAL NERVOUS SYSTEM. IV. DISTRIBUTION OF MONOAMINE NERVE TERMINALS IN THE CENTRAL NERVOUS SYSTEM. Acta Physiol Scand Suppl. 1965; :SUPPL 247:37+. View

20.

Shee J . Dangerous potentiation of pethidine by iproniazid, and its treatment. Br Med J. 1960; 2(5197):507-9. PMC: 2097120. DOI: 10.1136/bmj.2.5197.507. View