Regulation of Phosphate Metabolism in Neurospora Crassa. Characterization of Regulatory Mutants

Overview

Journal Genetics

Publisher Oxford University Press

Specialty Genetics

Date 1973 Sep 1

PMID 4271653

Citations 17

Authors

J F Lehman

M K Gleason

S K Ahlgren

R L Metzenberg

Affiliations

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Abstract

A mutant of Neurospora crassa, called UW-6, differs from wild type in being partially constitutive for synthesis of a species of alkaline phosphatase, and also for a species of phosphate permease that has a high affinity for phosphate at high pH. UW-6 is possibly allelic with a mutant called nuc-2 that was previously isolated by Ishikawa. nuc-2 has the converse phenotype, in that it cannot be derepressed for either of these two activities. UW-6 is co-dominant with its wild-type allele in heterokaryons and in partial diploids. An unlinked mutant, nuc-1, is like nuc-2 in that it fails to make the alkaline phosphatase or the permease referred to above. nuc-1 is epistatic to UW-6 in the double mutant. The control of phosphorus metabolism is discussed, and is compared with some other control systems in filamentous fungi.

Citing Articles

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NUC-2, a component of the phosphate-regulated signal transduction pathway in Neurospora crassa, is an ankyrin repeat protein.

Poleg Y, Aramayo R, Kang S, Hall J, Metzenberg R Mol Gen Genet. 1996; 252(6):709-16.

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Repressible extracellular phosphodiesterases showing cyclic 2',3'- and cyclic 3',5'-nucleotide phosphodiesterase activities in Neurospora crassa.

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Chromosomal loci of Neurospora crassa.

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Regulation of phosphate metabolism in Neurospora crassa: isolation of mutants deficient in ther repressible alkaline phosphatase.

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