Genetic Control of Phosphate-metabolizing Enzymes in Neurospora Crassa: Relationships Among Regulatory Mutations

Overview

Journal Genetics

Publisher Oxford University Press

Specialty Genetics

Date 1975 Mar 1

PMID 123873

Citations 22

Authors

B S Littlewood

W Chia

R L Metzenberg

Affiliations

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Abstract

In Neurospora crassa, the phosphate-metabolizing enzymes are made during phosphate starvation, but not under phosphate sufficiency. The synthesis of these enzymes is controlled by three regulatory genes: pcon-nuc-2, preg and nuc-1, pcon-nuc-2 and preg are closely linked. A model of the hierarchical relationships among these regulatory genes is presented. Studies of double mutants and revertants confirm several predictions of the model. It has been found that nuc-2 (null) and pcon-c (constitutive) mutations reside in the same cistron. preg-c (constitutive) mutations are epistatic to nuc-2 mutations. nuc-1 (null) mutations are epistatic to all others.

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References

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Gleason M, Metzenberg R . Regulation of phosphate metabolism in Neurospora crassa: isolation of mutants deficient in ther repressible alkaline phosphatase. Genetics. 1974; 78(2):645-59. PMC: 1213225. DOI: 10.1093/genetics/78.2.645. View

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