Article: Comparison of the antinociceptive activities of physostigmine, oxotremorine and morphine in the mouse

1. Morphine, oxotremorine and physostigmine showed antinociceptive activity in mice using the hot plate reaction time test.2. The action of morphine, but not that of oxotremorine, was antagonized by naloxone and by nalorphine, whereas the effect of physostigmine was unaffected by naloxone and increased by nalorphine.3. The antinociceptive effects of morphine and of physostigmine were increased by procedures reported to increase the ratio of 5-hydroxytryptamine to dopamine in the brain. It was decreased by procedures reported to cause a fall in brain 5-hydroxytryptamine or a rise in dopamine relative to 5-hydroxytryptamine.4. The antinociceptive effect of oxotremorine was potentiated by procedures reported to decrease brain noradrenaline and was unaffected by procedures altering brain 5-hydroxytryptamine.5. The results suggest differences in the mode of action of morphine and physostigmine on the one hand and of oxotremorine on the other.

Citing Articles

Slow-sustained delivery of naloxone reduces typical naloxone-induced precipitated opioid withdrawal effects in male morphine-dependent mice.

Lewter L, Johnson M, Treat A, Kassick A, Averick S, Kolber B J Neurosci Res. 2020; 100(1):339-352.

PMID: 32772457 PMC: 9809991. DOI: 10.1002/jnr.24627.

Comparative evaluation of different doses of intrathecal neostigmine as an adjuvant to bupivacaine for postoperative analgesia.

Pandey V, Mohindra B, Sodhi G Anesth Essays Res. 2016; 10(3):538-545.

PMID: 27746548 PMC: 5062199. DOI: 10.4103/0259-1162.180779.

The evolution of spinal/epidural neostigmine in clinical application: Thoughts after two decades.

Lauretti G Saudi J Anaesth. 2015; 9(1):71-81.

PMID: 25558203 PMC: 4279354. DOI: 10.4103/1658-354X.146319.

Analgesic efficacy of low-dose intrathecal neostigmine in combination with fentanyl and bupivacaine for total knee replacement surgery.

Jain A, Jain K, Bhardawaj N J Anaesthesiol Clin Pharmacol. 2012; 28(4):486-90.

PMID: 23225930 PMC: 3511947. DOI: 10.4103/0970-9185.101927.

Depression by nicotine of pain-related nociceptive activity in the rat thalamus and spinal cord.

Jurna I, Krauss P, Baldauf J Clin Investig. 1993; 72(1):65-73.

PMID: 8136621 DOI: 10.1007/BF00231121.

References

1.

Major C, Pleuvry B . Effects of alpha-methyl-p-tyrosine, p-chlorophenylalanine, l-beta-(3,4-dihydroxyphenyl)alanine, 5-hydroxytryptophan and diethyldithiocarbamate on the analgesic activity of morphine and methylamphetamine in the mouse. Br J Pharmacol. 1971; 42(4):512-21. PMC: 1665735. DOI: 10.1111/j.1476-5381.1971.tb07137.x. View

2.

Spector S . Inhibitors of endogenous catecholamine biosynthesis. Pharmacol Rev. 1966; 18(1):599-609. View

3.

Ireson J . A comparison of the antinociceptive actions of cholinomimetic and morphine-like drugs. Br J Pharmacol. 1970; 40(1):92-101. PMC: 1702687. DOI: 10.1111/j.1476-5381.1970.tb10614.x. View

4.

Fennessy M, Lee J . Modification of morphine analgesia by drugs affecting adrenergic and tryptaminergic mechanisms. J Pharm Pharmacol. 1970; 22(12):930-5. DOI: 10.1111/j.2042-7158.1970.tb08475.x. View

5.

Harris L, Dewey W, Howes J, Kennedy J, Pars H . Narcotic-antagonist analgesics: interactions with cholinergic systems. J Pharmacol Exp Ther. 1969; 169(1):17-22. View

6.

KOE B, Weissman A . p-Chlorophenylalanine: a specific depletor of brain serotonin. J Pharmacol Exp Ther. 1966; 154(3):499-516. View

7.

Sethy V, Naik S, sheth U . The effect of drugs influencing amine synthesis on the analgesic action of tremorine. Psychopharmacologia. 1971; 19(1):73-80. DOI: 10.1007/BF00403705. View

8.

SOMERVILLE A, WHITTLE B . The interrelation of hypothermia and depletion of noradrenaline, dopamine and 5-hydroxytryptamine from brain by reserpine, para-chlorophenylalanine and alpha-methylmetatyrosine. Br J Pharmacol Chemother. 1967; 31(1):120-31. PMC: 1557286. DOI: 10.1111/j.1476-5381.1967.tb01982.x. View

9.

Bousfield J, Rees J . The analgesic and respiratory depressant activities of N-allyl noretrophine and morphine in the mouse. J Pharm Pharmacol. 1969; 21(9):630-2. DOI: 10.1111/j.2042-7158.1969.tb08337.x. View

10.

Chen G . The anti-tremorine effect of some drugs as determined by Haffner's method of testing analgesia in mice. J Pharmacol Exp Ther. 1958; 124(1):73-6. View

11.

Lotti V, Porter C . Potentiation and inhbition of some central actions of L(-)-dopa by decarboxylase inhibitors. J Pharmacol Exp Ther. 1970; 172(2):406-15. View

12.

Carlsson A, Lindqvist M, Fuxe K, Hokfelt T . Histochemical amd biochemical effects of diethyldithiocarbamate on tissue catecholamines. J Pharm Pharmacol. 1966; 18(1):60-2. DOI: 10.1111/j.2042-7158.1966.tb07773.x. View

Comparison of the Antinociceptive Activities of Physostigmine, Oxotremorine and Morphine in the Mouse