3-acetylpyridine: Effects in Vitro Related to Teratogenic Activity in Chicken Embryos

Overview

Journal Science

Specialty Science

Date 1968 May 31

PMID 4231047

Citations 11

Authors

A I Caplan

E ZWILLING

N O Kaplan

Affiliations

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Abstract

Production of skeletal muscle hypoplasia by 3-acetylpyridine and its complete reversal by nicotinamide in developing chicken embryos have been confirmed. Cultures of developing embryonic chicken muscle show degenerative effects produced by 3-acetylpyridine; these effects are reversed by nicotinamide. Cartilage production in cultured chondrogenic cells is potentiated by 3-acetylpyridine; this potentiation is completely reversed by nicotinamide. It is suggested that nicotinamide-or pyridine-nucleotide-dependent reactions influence normal differentiation of limb mesoderm cells by inhibiting chondrogenic-cell and potentiating muscle-cell expression or proliferation.

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