Mode of Action of the 2-nitroimidazole Derivative Benznidazole

Overview

Journal Ann Trop Med Parasitol

Specialties Parasitology
Tropical Medicine

Date 1978 Feb 1

PMID 418744

Citations 12

Authors

A Polak

R RICHLE

Affiliations

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Abstract

Using cultures of Trypanosoma cruzi cells in a liquid medium, the mode of action of the 2-nitroimidazole derivative benznidazole was examined. Benznidazole inhibits protein synthesis and RNA synthesis in T. cruzy. The DNA synthesis is only slightly decreased and no effect on the aerobic respiration of T. cruzi was observed.

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