Interaction of Benznidazole Reactive Metabolites with Nuclear and Kinetoplastic DNA, Proteins and Lipids from Trypanosoma Cruzi

Overview

Journal Experientia

Specialty Science

Date 1988 Oct 15

PMID 3053234

Citations 18

Authors

E G Diaz de Toranzo

J A Castro

B M Franke De Cazzulo

J J Cazzulo

Affiliations

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Abstract

Epimastigotes of Trypanosoma cruzi (Tulahuen strain Tul 0 stock) biotransform benznidazole (N-benzyl-2-nitro-1-imidazole acetamide) to reactive metabolites that bind covalently to DNA, proteins and lipids of the parasite. These effects might be related to the trypanocidal action of benznidazole, a chemotherapeutic agent against Chagas' disease.

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