Relative Inability to Induce Tolerance in Adult NZB and NZB-NZW F1 Mice

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1969 Jan 1

PMID 4178111

Citations 54

Authors

P J Staples

N Talal

Affiliations

Soon will be listed here.

Abstract

Immunologic tolerance to ultracentrifuged bovine gamma globulin could not be induced in 6-wk old NZB or B/W mice, but developed readily in C3H, NZW, and C57Bl mice. NZB and B/W mice, as well as Balb/c mice, failed to become tolerant to ultracentrifuged human gamma globulin. The NZB and B/W mice also showed higher antibody titers to a standard antigenic challenge. This immunologic hyperreactivity and lack of experimental tolerance may be related to the lack of self-tolerance, autoimmunity, and lymphomas that develop in these mice at a later age.

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