Studies on Rabbit Lymphocytes in Vitro. IX. The Suppression of Antiallotype-induced Blast Transformation in Lymphocyte Cultures from Allotypically Suppressed Donors

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1968 Aug 1

PMID 4173342

Citations 6

Authors

S Sell

Affiliations

Soon will be listed here.

Abstract

The number of lymphocytes transformed in vitro by antiallotype sera in cultures obtained from allotypically suppressed rabbits is significantly less than that induced in cultures from normal rabbits. There is a compensatory increase in the amount of transformation induced by antiallotype sera directed toward the unsuppressed allotype. Thus the control of allotypic expression is suppressed rabbits appears to be the same for lymphocytes and for plasma cells.

Citing Articles

Allotypic suppression of adult mouse spleen cells.

Anderson H Immunology. 1970; 19(1):169-79.

PMID: 4922028 PMC: 1455615.

Humoral and cellular aspects of immunoglobulin allotype suppression in the rabbit. I. Kinetics of neutralization of suppression.

Lowe J, Cross L, Catty D Immunology. 1973; 25(3):367-75.

PMID: 4742046 PMC: 1423063.

The activity of homologous and heterologous anti-allotypic sera in transformation and allotypic suppression in rabbits.

Lowe J Immunology. 1972; 23(4):591-7.

PMID: 4628465 PMC: 1407977.

Transformation of rabbit lymphocytes by anti-allotype serum: ultrastructure of transformed cells and suppression of responding cells by foetal exposure to anti-allotype serum.

Marcuson E, Roitt I Immunology. 1969; 16(6):791-802.

PMID: 4182370 PMC: 1409665.

Deletion of b5 immunoglobulin-bearing lymphocytes in allotype-suppressed rabbits.

Harrison M, MAGE R, Davie J J Exp Med. 1973; 137(2):254-64.

PMID: 4119585 PMC: 2139501. DOI: 10.1084/jem.137.2.254.

References

BERNIER G, Cebra J . Frequency distribution of alpha, gamma, kappa and lambda polypeptide chains in human lymphoid tissues. J Immunol. 1965; 95(2):246-53. View

Gell P, Sell S . Studies on rabbit lymphocytes in vitro. II. Induction of blast transformation with antisera to six IgG allotypes and summation with mixtures of antisera to different allotypes. J Exp Med. 1965; 122(4):813-21. PMC: 2138082. DOI: 10.1084/jem.122.4.813. View

Pernis B, Chiappino G, KELUS A, Gell P . Cellular localization of immunoglobulins with different allotypic specificities in rabbit lymphoid tissues. J Exp Med. 1965; 122(5):853-76. PMC: 2138120. DOI: 10.1084/jem.122.5.853. View

Cebra J, COLBERG J, Dray S . Rabbit lymphoid cells differentiated with respect to alpha-, gamma-, and mu- heavy polypeptide chains and to allotypic markers Aa1 and Aa2. J Exp Med. 1966; 123(3):547-58. PMC: 2138155. DOI: 10.1084/jem.123.3.547. View

Small Jr P, Lamm M . Polypeptide chain structure of rabbit immunoglobulins. I. gamma-G-immunoglobulin. Biochemistry. 1966; 5(1):259-67. DOI: 10.1021/bi00865a034. View

Lamm M, Small Jr P . Polypeptide chain structure of rabbit immunoglobulins. II. gamma-M-immunoglobulin. Biochemistry. 1966; 5(1):267-76. DOI: 10.1021/bi00865a035. View

DUBISKI S, Fradette K . The feed-back mechanism in immunoglobulin synthesis. Proc Soc Exp Biol Med. 1966; 122(1):126-30. DOI: 10.3181/00379727-122-31070. View

Van Furth R, SCHUIT H, HIJMANS W . The formation of immunoglobulins by human tissues in vitro. 3. Spleen, lymph nodes, bone marrow and thymus. Immunology. 1966; 11(1):19-27. PMC: 1423753. View

Sell S . Studies on rabbit lymphocytes in vitro. VI. The induction of blast transformation with sheep antisera to rabbit IgA and IgM. J Exp Med. 1967; 125(3):393-400. PMC: 2138297. DOI: 10.1084/jem.125.3.393. View

10.

Sell S . Studies on rabbit lymphocytes in vitro. V. The induction of blast transformation with sheep antisera to rabbit IgG subunits. J Exp Med. 1967; 125(2):289-301. PMC: 2138360. DOI: 10.1084/jem.125.2.289. View

11.

Mage R, Young G, Dray S . An effect upon the regulation of gene expression: allotype suppression at the a locus in heterozygous offspring of immunized rabbits. J Immunol. 1967; 98(3):502-9. View

12.

Cebra J, Small Jr P . Polypeptide chain structure of rabbit immunoglobulins. 3. Secretory gamma-A-immunoglobulin from colostrum. Biochemistry. 1967; 6(2):503-12. DOI: 10.1021/bi00854a019. View

13.

KELUS A, Gell P . Immunoglobulin allotypes of experimental animals. Prog Allergy. 1967; 11:141-84. View

14.

DUBISKI S, Muller P . A "new" allotypic specificity (A9) of rabbit immunoglobulin. Nature. 1967; 214(5089):696-7. DOI: 10.1038/214696a0. View

15.

Lummus Z, Cebra J, Mage R . Correspondence of the relative cellular distribution and serum concentration of allelic allotypic markers in normal and "allotype-suppressed" heterozygous rabbits. J Immunol. 1967; 99(4):737-43. View

16.

Herzenberg L, Goodlin R, Rivera E . Immunoglobulin synthesis in mice: suppression by anti-allotype antibody. J Exp Med. 1967; 126(4):701-13. PMC: 2138387. DOI: 10.1084/jem.126.4.701. View

17.

DUBISKI S . Suppression of synthesis of allotypically defined immunoglobulins and compensation by another sub-class of immunoglobulin. Nature. 1967; 214(5095):1365-6. DOI: 10.1038/2141365a0. View

18.

Sell S . Studies on rabbit lymphocytes in vitro. 8. The relationship between heterozygosity and homozygosity of lymphocyte donor and per cent blast transformation induced by antiallotype sera. J Exp Med. 1968; 127(6):1139-48. PMC: 2138501. DOI: 10.1084/jem.127.6.1139. View

19.

Stavitsky A . Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. J Immunol. 1954; 72(5):360-7. View

20.

White R . Observations on the formation and nature of Russell bodies. Br J Exp Pathol. 1954; 35(4):365-76. PMC: 2073666. View