A Radioimmunoassay for Human Thyroglobulin: Methodology and Clinical Applications

Overview

Journal Eur J Clin Invest

Publisher Wiley

Specialty General Medicine

Date 1977 Dec 1

PMID 415873

Citations 6

Authors

V Pezzino

P Cozzani

S Filetti

A Galbiati

E Lisi

S Squatrito

R Vigneri

Affiliations

Soon will be listed here.

Abstract

A specific double-antibody radioimmunoassay with a sensitivity of 2.5 ng/ml has been developed for measuring thyroglobulin (Tg) in human serum. As endogenous anti-Tg antibodies in serum interfere in the assay, only sera with a negative tanned red cell (TRC) test are suitable for analysis. Tg was detectable in 84.7% of the euthyroid subjects, with a mean value of 6.1 (values ranging from nondetectable to 43.0 ng/ml). Values were significantly higher in women than in men. Tg release by the thyroid appears to be under pituitary control, as suggested by TSH stimulation and T3 suppression tests. Elevated Tg levels were found in hyperthyroidism, simple goitre, and differentiated thyroid carcinoma. The significance of circulating Tg and the possible application of the Tg RIA are discussed.

Citing Articles

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Endemic cretinism in Sicily.

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The value of serum thyroglobulin measurement as a marker of cancer recurrence in the follow-up of patients previously treated for differentiated thyroid tumor.

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Evidence for autonomous thyroglobulin release from euthyroid and hyperthyroid nodular goiter--thyroglobulin, a possible helpful parameter in diagnosis of non-malignant thyroid disorders.

Gartner R, Hainzinger A, Horn K, Pickardt R Klin Wochenschr. 1983; 61(15):737-41.

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Increased level of thyroglobulin mRNA in a human familial goiter.

Monticelli A, Avvedimento V, Mariano A, Marcocci C, Chiovato L, Fenzi G J Endocrinol Invest. 1987; 10(1):59-63.

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