Increased Level of Thyroglobulin MRNA in a Human Familial Goiter

Overview

Journal J Endocrinol Invest

Publisher Springer

Specialty Endocrinology

Date 1987 Feb 1

PMID 3110253

Authors

A Monticelli

V E Avvedimento

A Mariano

C Marcocci

L Chiovato

G F Fenzi

A Pinchera

S VARRONE

Affiliations

Soon will be listed here.

Abstract

Thyroglobulin (Tg) and its specific mRNA were analyzed in the thyroid gland of two cases of familial goiter. A three-fold increase in the level of stable protein and functional Tg mRNA was found in the goiter of one of the two patients in whom a desiodase defect was demonstrated. Normal concentrations of both Tg and its mRNA were found in the other goiter in which no enzymatic defect could be shown. Our results suggest that the increase of Tg mRNA levels found in the goiter with a desiodase defect was due to a chronic stimulation of the gland by TSH.

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