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» Articles » PMID: 4157340

Cinoxacin: Effectiveness Against Experimental Pyelonephritis in Rats

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 1974 Oct 1
PMID 4157340
Citations 3
Authors
D H HOLMES
P W ENSMINGER
R S GORDEE
Affiliations
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Abstract

The antimicrobial activity of cinoxacin, 1-ethyl-4(1H)-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid, previously reported as compound 64716, was determined and compared with other antimicrobial agents at a dosage of 12 mg/kg once daily in a descending pyelonephritis rat model with Escherichia coli and Proteus mirabilis as infecting organisms. Cinoxacin was considerably more effective than either nalidixic acid or oxolinic acid when all three were administered orally at 3 mg/kg four times daily. The presence of demonstrable serum activity with a high recovery in urine indicates cinoxacin possesses highly desirable properties of an effective oral chemotherapeutic agent for urinary tract infections.

Citing Articles

[A comparison of cinoxacin and nalidixic acid in the treatment of chronic urinary tract infections].

BRIEDIGKEIT H, Schimmelpfennig R, Buder R, Precht K, Droseler H Infection. 1982; 10(4):219-22.

PMID: 7129643 DOI: 10.1007/BF01666914.

Antibacterial activity of cinoxacin in vitro.

Giamarellou H, JACKSON G Antimicrob Agents Chemother. 1975; 7(5):688-92.

PMID: 1096811 PMC: 429204. DOI: 10.1128/AAC.7.5.688.

In vitro antimicrobial activity of cinoxacin against 2,968 clinical bacterial isolates.

Jones R, Fuchs P Antimicrob Agents Chemother. 1976; 10(1):146-9.

PMID: 984747 PMC: 429704. DOI: 10.1128/AAC.10.1.146.

References
1.
Beeson P, Guze L . Experimental pyelonephritis. I. Effect of ureteral ligation on the course of bacterial infection in the kidney of the rat. J Exp Med. 1956; 104(6):803-15. PMC: 2136652. DOI: 10.1084/jem.104.6.803. View
2.
English A . Activity of tetracyclines, nalidixic acids, and nitrofurantoin in two experimental models of Escherichia coli urinary tract disease in rats. Proc Soc Exp Biol Med. 1971; 136(4):1094-6. DOI: 10.3181/00379727-136-35435. View
3.
English A, Retsema J, Ray V, LYNCH J . Carbenicillin indanyl sodium, an orally active derivative of carbenicillin. Antimicrob Agents Chemother. 1972; 1(3):185-91. PMC: 444190. DOI: 10.1128/AAC.1.3.185. View
4.
WICK W, Preston D, White W, GORDEE R . Compound 64716, a new synthetic antibacterial agent. Antimicrob Agents Chemother. 1973; 4(4):415-20. PMC: 444569. DOI: 10.1128/AAC.4.4.415. View
5.
Cooper M, Anders M, Mirkin B . Ion-pair extraction and high-speed liquid chromatography of cephalothin and deacetylcephalothin in human serum and urine. Drug Metab Dispos. 1973; 1(5):659-62. View