The Effects E and A Prostaglandins on Gastric Mucosal Blood Flow and Acid Secretion in the Rat

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1973 Nov 1

PMID 4149696

Citations 38

Authors

I H MAIN

B J Whittle

Affiliations

Soon will be listed here.

Abstract

1. The effects of prostaglandins E(1), E(2), A(1) and A(2) on gastric acid secretion and mucosal blood flow were studied by means of a [(14)C]-aniline clearance technique in the anaesthetized rat.2. During intravenous administration of these prostaglandins, in doses which almost completely inhibited pentagastrin- and histamine-induced acid secretion, a fall in clearance was observed.3. Clearance per unit acid secretion increased during prostaglandin administration, precluding a primary reduction in mucosal blood flow as the mechanism of the antisecretory action.4. Prostaglandins increased clearance during basal secretion, indicating a direct vasodilator effect on the gastric mucosa.5. The possibility that endogenous prostaglandins contribute to functional vasodilatation in the gastric mucosa and that exogenous prostaglandins may be of clinical value in the treatment of peptic ulcer is discussed.

Citing Articles

Study of Melatonin as Preventive Agent of Gastrointestinal Damage Induced by Sodium Diclofenac.

B Sanchez A, Clares B, Rodriguez-Lagunas M, Fabrega M, Calpena A Cells. 2020; 9(1).

PMID: 31936877 PMC: 7016873. DOI: 10.3390/cells9010180.

The Physiology of the Gastric Parietal Cell.

Engevik A, Kaji I, Goldenring J Physiol Rev. 2019; 100(2):573-602.

PMID: 31670611 PMC: 7327232. DOI: 10.1152/physrev.00016.2019.

Synthesis and pharmacological evaluation of pyrazolopyrimidopyrimidine derivatives: anti-inflammatory agents with gastroprotective effect in rats.

Karoui A, Allouche F, Deghrigue M, Agrebi A, Bouraoui A, Chabchoub F Med Chem Res. 2014; 23:1591-1598.

PMID: 24489456 PMC: 3905175. DOI: 10.1007/s00044-013-0742-x.

Anti-ulcerogenic activity of the methanol root bark extract of Cochlospermum planchonii (Hook f).

Ezeja M, Anaga A Afr J Tradit Complement Altern Med. 2013; 10(5):394-400.

PMID: 24311856 PMC: 3847436. DOI: 10.4314/ajtcam.v10i5.29.

Increased gastric bicarbonate secretion in portal hypertensive anesthetized rats: role of prostaglandins and nitric oxide.

Lamarque D, Dutreuil C, Dhumeaux D, Delchier J Dig Dis Sci. 1997; 42(4):743-50.

PMID: 9125643 DOI: 10.1023/a:1018851727844.

References

Jacobson E, LINFORD R, GROSSMAN M . Gastric secretion in relation to mucosal blood flow studied by a clearance technic. J Clin Invest. 1966; 45(1):1-13. PMC: 292662. DOI: 10.1172/JCI105313. View

Robert A, NEZAMIS J, Phillips J . Inhibition of gastric secretion by prostaglandins. Am J Dig Dis. 1967; 12(10):1073-6. DOI: 10.1007/BF02233268. View

Robert A, NEZAMIS J, Phillips J . Effect of prostaglandin E1 on gastric secretion and ulcer formation in the rat. Gastroenterology. 1968; 55(4):481-7. View

Way L, Durbin R . Inhibition of gastric acid secretion in vitro by prostaglandin E1. Nature. 1969; 221(5183):874-5. DOI: 10.1038/221874a0. View

Horton E, MAIN I, Thompson C, Wright P . Effect of orally administered prostaglandin E1 on gastric secretion and gastrointestinal motility in man. Gut. 1968; 9(6):655-8. PMC: 1552878. DOI: 10.1136/gut.9.6.655. View

Carlson L, EKELUND L, Oro L . Circulatory and respiratory effects of different doses of prostaglandin E1 in man. Acta Physiol Scand. 1969; 75(1):161-9. DOI: 10.1111/j.1748-1716.1969.tb04368.x. View

Jacobson E . Comparison of prostaglandin E1 and norepinephrine on the gastric mucosal circulation. Proc Soc Exp Biol Med. 1970; 133(2):516-9. DOI: 10.3181/00379727-133-34509. View

Augur Jr N . Gastric mucosal blood flow following damage by ethanol, acetic acid, or aspirin. Gastroenterology. 1970; 58(3):311-20. View

RUDICK J, WERTHER J, Chapman M, DREILING D, Janowitz H . Mucosal blood flow in canine antral and fundic pouches. Gastroenterology. 1971; 60(2):263-71. View

10.

Robert A, Stowe D, NEZAMIS J . Prevention of duodenal ulcers by administration of prostaglandin E 2 (PGE 2 ). Scand J Gastroenterol. 1971; 6(4):303-5. DOI: 10.3109/00365527109181124. View

11.

Wilson D, Phillips C, Levine R . Inhibition of gastric secretion in man by prostaglandin A. Gastroenterology. 1971; 61(2):201-6. View

12.

Vane J . Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971; 231(25):232-5. DOI: 10.1038/newbio231232a0. View

13.

Classen M, Koch H, Bickhardt J, Topf G, DEMLING L . The effect of prostaglandin E 1 on the pentagastrin-stimulated gastric secretion in man. Digestion. 1971; 4(6):333-44. DOI: 10.1159/000197138. View

14.

Wilson D, Levine R . The effect of prostaglandin E 1 on canine gastric acid secretion and gastric mucosal blood flow. Am J Dig Dis. 1972; 17(6):527-32. DOI: 10.1007/BF02231209. View

15.

Karim S, Carter D, Bhana D, Ganesan P . Effect of orally administered prostaglandin E 2 and its 15-methyl analogues on gastric secretion. Br Med J. 1973; 1(5846):143-6. PMC: 1588413. DOI: 10.1136/bmj.1.5846.143. View

16.

MAIN I, Whittle B . Effects of indomethacin on rat gastric acid secretion and mucosal blood flow. Br J Pharmacol. 1973; 47(3):666P. PMC: 1776367. View

17.

MAIN I, Whittle B . Proceedings: Effects of prostaglandin E2 on rat gastric mucosal blood flow, as determined by 14C-aniline clearance. Br J Pharmacol. 1972; 44(2):331P-332P. PMC: 1666047. View

18.

MAIN I, Whittle B . Gastric mucosal blood flow during pentagastrin- and histamine-stimulated acid secretion in the rat. Br J Pharmacol. 1973; 49(3):534-42. PMC: 1776483. DOI: 10.1111/j.1476-5381.1973.tb17264.x. View

19.

GHOSH M, SCHILD H . Continuous recording of acid gastric secretion in the rat. Br J Pharmacol Chemother. 1958; 13(1):54-61. PMC: 1481706. DOI: 10.1111/j.1476-5381.1958.tb00190.x. View