An Immunoglobulin Heavy Chain Variable Region (VH) Marker Associated with Cross-reactive Idiotypes in Man

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1977 Nov 1

PMID 414866

Citations 3

Authors

T Feizi

J LECOMTE

R Childs

Affiliations

Soon will be listed here.

Abstract

The VH specificities of two rabbit antisera raised against the H chains of two human IgM cold agglutinins were studied with the aid of proteins on which the VH sequence data are available. They were found to recognize a new VH antigen (VHMar), which may represent a subgroup of VHI. This antigen is found on anti-Ii antibodies which have cross-reactive idiotypes. It is moderately well-expressed in normal gamma globulin and strongly expressed on 8% of unselected myeloma and macroglobulinaemia proteins. There is evidence to suggest that a proportion of the cross-reactive idiotypes among the anti-Ii antibodies involve this VH antigen.

Citing Articles

Anti-idiotypic antibodies to the Coombs antibody in NZB F1 mice.

Cohen P, Eisenberg R J Exp Med. 1982; 156(1):173-80.

PMID: 6979603 PMC: 2186743. DOI: 10.1084/jem.156.1.173.

Investigation of the idiotypic determinants of IgM monoclonal proteins associated with neuropathy.

Evans S, Gregson N, Leibowitz S, LING N Clin Exp Immunol. 1984; 57(3):621-5.

PMID: 6205799 PMC: 1536269.

Immunoglobulin VH determinants defined by monoclonal antibodies.

Kubagawa H, Mayumi M, Kearney J, Cooper M J Exp Med. 1982; 156(4):1010-24.

PMID: 6185604 PMC: 2186823. DOI: 10.1084/jem.156.4.1010.

References

OUDIN J, Cazenave P . Similar idiotypic specificities in immunoglobulin fractions with different antibody functions or even without detectable antibody function. Proc Natl Acad Sci U S A. 1971; 68(10):2616-20. PMC: 389480. DOI: 10.1073/pnas.68.10.2616. View

Childs R, Feizi T . Cross idiotypic specificity among heavy chains of macroglobulins with blood group I and i specificities. Nature. 1975; 255(5509):562-4. DOI: 10.1038/255562a0. View

Wolfenstein-Todel C, Frangione B, FRANKLIN E . Partial amino acid sequence of an IgA2 human immunoglobulin heavy chain. Biochim Biophys Acta. 1975; 379(2):627-37. DOI: 10.1016/0005-2795(75)90169-5. View

Kratzin H, Altevogt P, RUBAN E, Kortt A, Staroscik K, Hilschmann N . [The primary structure of a monoclonal IgA-immunoglobulin (IgA Tro.), II. The amino acid sequence of the H-chain, alpha-type, subgroup III; structure of the complete IgA-molecule (author's transl)]. Hoppe Seylers Z Physiol Chem. 1975; 356(8):1337-42. View

Solomon A, McLaughlin C . Bence Jones proteins and light chains of immunoglobulins. IV. Immunochemical differentiation among proteins within each of the three established kappa-chain classes. J Immunol. 1971; 106(1):120-7. View

Feizi T, KUNKEL H, Roelcke D . Cross idiotypic specificity among cold agglutinins in relation to combining activity for blood group-related antigens. Clin Exp Immunol. 1974; 18(2):283-93. PMC: 1537898. View

KUNKEL H, Winchester R, Joslin F, Capra J . Similarities in the light chains of anti-gamma-globulins showing cross-idiotypic specificities. J Exp Med. 1974; 139(1):128-36. PMC: 2139505. DOI: 10.1084/jem.139.1.128. View

Laure C, Watanabe S, Hilschmann N . [The primary structure of a monoclonal IgM-immunoglobulin (macroglobulin Gal.), I. The amino acid sequence of the L-chain of kappa-type, subgroup I (author's transl)]. Hoppe Seylers Z Physiol Chem. 1973; 354(10-11):1503-4. View

Florent G, Lehman D, Putnam F . The switch point in mu heavy chains of human IgM immunoglobulins. Biochemistry. 1974; 13(12):2482-98. DOI: 10.1021/bi00709a004. View

10.

Edelman G, Cunningham B, Gall W, Gottlieb P, Rutishauser U, Waxdal M . The covalent structure of an entire gammaG immunoglobulin molecule. Proc Natl Acad Sci U S A. 1969; 63(1):78-85. PMC: 534037. DOI: 10.1073/pnas.63.1.78. View

11.

Gergely J, Wang A, Fudenberg H . Chemical analyses of variable regions of heavy and light chains of cold agglutinins. Vox Sang. 1973; 24(5):432-40. DOI: 10.1111/j.1423-0410.1973.tb03484.x. View

12.

Kaplan A, HOOD L, TERRY W, Metzger H . Amino terminal sequences of human immunoglobulin heavy chains. Immunochemistry. 1971; 8(9):801-11. DOI: 10.1016/0019-2791(71)90447-2. View

13.

Fisher C, Palm W, PRESS E . The N-terminal sequence of a human gamma 1 chain of allotype Gm(a(-)f(+)). FEBS Lett. 1969; 5(1):20-22. DOI: 10.1016/0014-5793(69)80282-6. View

14.

FRANKLIN E, Frangione B . Structural differences between macroglobulins belonging to two serologically distinguishable subclasses. Biochemistry. 1968; 7(12):4203-11. DOI: 10.1021/bi00852a010. View

15.

Capra J, Kehoe J . Variable region sequences of five human immunoglobulin heavy chains of the VH3 subgroup: definitive identification of four heavy chain hypervariable regions. Proc Natl Acad Sci U S A. 1974; 71(3):845-8. PMC: 388111. DOI: 10.1073/pnas.71.3.845. View

16.

Putnam F, Florent G, Paul C, Shinoda T, Shimizu A . Complete amino acid sequence of the Mu heavy chain of a human IgM immunoglobulin. Science. 1973; 182(4109):287-91. DOI: 10.1126/science.182.4109.287. View

17.

FRANKLIN E, Frangione B . Two serologically distinguishable subclasses of mu-chains of human macroglobulins. J Immunol. 1967; 99(4):810-4. View

18.

Willims Jr R, KUNKEL H, Capra J . Antigenic specificities related to the cold agglutinin activity of gamma M globulins. Science. 1968; 161(3839):379-81. DOI: 10.1126/science.161.3839.379. View

19.

Pitcher S, Konigsberg W . The sequence of the NH2-terminal cyanogen bromide fragment from the heavy chain of a gamma-G1 myeloma protein. J Biol Chem. 1970; 245(6):1267-74. View

20.

Cunningham B, Pflumm M, Rutishauser U, Edelman G . Subgroups of amino acid sequences in the variable regions of immunoglobulin heavy chains. Proc Natl Acad Sci U S A. 1969; 64(3):997-1003. PMC: 223334. DOI: 10.1073/pnas.64.3.997. View