Human Regulatory Gene for Inducible Tyrosine Aminotransferase in Rat-human Hybrids

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1973 Apr 1

PMID 4146214

Citations 20

Authors

C M Croce

G Litwack

H KOPROWSKI

Affiliations

Soon will be listed here.

Abstract

The inducibility of tyrosine aminotransferase (EC 2.6.1.5) by corticosteroid hormones in rat-human hybrid clones was studied. The presence of human X chromosome activity in the cells was always associated with the suppression of tyrosine aminotransferase inducibility in all the clones examined. Negative correlation between the human X chromosome and inducibility of the enzyme was clearly established. Corticosteroid receptor was present to the same extent in hybrid cell clones that either contained or lost the human X chromosome. The human repressor for inducible tyrosine aminotransferase has a linkage relationship with glucose-6-phosphate dehydrogenase (EC 1.1.1.49) and hypoxanthine-guanine-phosphoribosyltransferase (EC 2.4.2.8) and, therefore, can be assigned to the X chromosome.

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