Third Party Mixed-leukocyte Culture Test: a Potential New Method of Histocompatibility Testing

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1972 Jun 1

PMID 4113869

Citations 1

Authors

B H Park

R A GOOD

Affiliations

Soon will be listed here.

Abstract

The disparity index is an expression of histocompatibility difference between two siblings with identical human leukocyte antigen (HL-A) type who are nonreactive in mixed leukocyte culture (MLC) test. This index is derived from a third-party MLC test. The disparity index was found to be correlated with the severity of graft-versus-host reaction in bone marrow transplantation between HL-A-identical siblings. The disparity index may prove to be a useful means of predicting the severity of graft-versus-host reaction and the outcome of bone marrow graft when HL-A- and MLC-matched sibling donors are studied. The third-party MLC test is offered as a new method of histocompatibility testing. It may provide a useful model for the study of immunogenetics relative to so-called weaker histocompatibility determinants in man and experimental animals.

Citing Articles

Synergism of stimulating capacity of pooled lymphocytes in the mixed lymphocyte reaction.

Han T, Pauly J Immunology. 1973; 24(5):895-9.

PMID: 4268452 PMC: 1422818.

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