Murine Plasma Cells Secreting More Than One Class of Immunoglobulin Heavy Chain. IV. Sequence Differences Between Kappa-chains of SAMM 368 IgG2b and IgA

The amino terminal sequences of the kappa light chains from SAMM 368 IgG2b and IgA have been determined. The two chains belong to different kappa subgroups as indicated by 10 amino acid differences among the first 23 residues. An additional three residue differences were demonstrated in the sequence including the first complementarity region. These results indicate that single cells of SAMM 368 produce two unique kappa-chains.