Increased Arterial Stiffness in Normotensive Individuals with Hypoparathyroidism

Overview

Journal Sci Rep

Specialty Science

Date 2025 Mar 15

PMID 40087339

Authors

Luciana N Cosenso-Martin

Rodrigo Duart Martins Souza

Jessica R Roma Uyemura

Valquiria da Silva Lopes

Leticia A Barufi Fernandes

Kleber Aparecido de Oliveira

Amanda Oliva Spaziani

Juan Carlos Yugar-Toledo

Marco Antonio Vieira Silva

Jose Fernando Vilela-Martin

Affiliations

Soon will be listed here.

Abstract

Hypoparathyroidism is the inability of parathyroid hormone (PTH) to maintain calcium homeostasis. Patients with post-surgical hypoparathyroidism may have an increased risk of mortality; there is clinical and molecular evidence of the effects of this condition on the cardiovascular system. The aim of this study was to evaluate arterial stiffness by measuring the carotid-femoral pulse wave velocity (PWV) in post-surgical hypoparathyroidism patients. A cross-sectional study was conducted with 30 post-surgical hypoparathyroidism patients and 25 volunteers from the Endocrinology Outpatient Clinic of the Medical School. The SphygmoCor system was used to evaluate arterial stiffness by analyzing the PWV. The mean ages of the hypoparathyroidism (50.4 years) and control individuals (49.6 years) were similar. The mean PWVs were 8.7 and 7.5 m/s in the Hypoparathyroidism and Control groups, respectively (p-value = 0.084). Considering only normotensive patients, PWV was statistically higher in the Hypoparathyroidism Group (7.6 versus 6.5 m/s; p-value = 0.039). For this group, serum ionized calcium, phosphorus, and the calcium x phosphorus product levels were positively associated to PWV. Hypoparathyroidism increases arterial stiffness as assessed by PWV. Serum ionized calcium, phosphorus, and the calcium x phosphorus product are affected. A more effective investigative and therapeutic approach for patients with hypoparathyroidism can help control cardiovascular risk.

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