The Parathyroid Gland and Heart Disease

Overview

Journal Methodist Debakey Cardiovasc J

Specialty Cardiology & Vascular Diseases

Date 2017 Jul 26

PMID 28740581

Citations 44

Authors

Spandana J Brown

Mary D Ruppe

Laila S Tabatabai

Affiliations

Soon will be listed here.

Abstract

The parathyroid glands are critical to maintaining calcium homeostasis through actions of parathyroid hormone (PTH). Recent clinical and molecular research has shown that direct and indirect actions of PTH also affect the heart and vasculature through downstream actions of G protein-coupled receptors in the myocardium and endothelial cells. Patients with disorders of the parathyroid gland have higher incidences of hypertension, arrhythmias, left ventricular hypertrophy, heart failure, and calcific disease which translate into increased cardiac morbidity and mortality. Importantly, clinical research also suggests that early treatment of parathyroid disorders through medical or surgical management may reverse cardiovascular remodeling and mitigate cardiac risk factors.

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