Role of Innate Immunity in SARS-CoV-2 Infection

Overview

Journal Biosaf Health

Date 2025 Mar 13

PMID 40078906

Authors

Zihao Wang

Fang Cheng

Yuxiu Xu

Xin Li

Songdong Meng

Affiliations

Soon will be listed here.

Abstract

During severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, activated macrophages, dendritic cells (D.C.), neutrophils, and natural killer (N.K.) cells are the first defense against infection. These immune effectors trap and ingest the virus, kill infected epithelial cells, or produce anti-viral cytokines. Evidence suggests that aging, obesity, and mental illness can lead to weakened innate immunity and, thus, are all associated with elevated infection and severe disease progression of coronavirus disease 2019 (COVID-19). Innate immune defense networks play a fundamental role in suppressing viral replication, infection establishment, and viral pathogenesis of SARS-CoV-2 and other respiratory viruses.

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