Vitamin D3: a Helpful Immuno-modulator

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 2011 Sep 8

PMID 21896008

Citations 173

Authors

Michelino Di Rosa

Michele Malaguarnera

Ferdinando Nicoletti

Lucia Malaguarnera

Affiliations

Soon will be listed here.

Abstract

The active metabolite of vitamin D, 1α, 25-dihydroxyvitamin D3 [1,25(OH)(2) D3], is involved in calcium and phosphate metabolism and exerts a large number of biological effects. Vitamin D3 inhibits parathyroid hormone secretion, adaptive immunity and cell proliferation, and at the same time promotes insulin secretion, innate immunity and stimulates cellular differentiation. The role of vitamin D3 in immunoregulation has led to the concept of a dual function as both as an important secosteroid hormone for the regulation of body calcium homeostasis and as an essential organic compound that has been shown to have a crucial effect on the immune responses. Altered levels of vitamin D3 have been associated, by recent observational studies, with a higher susceptibility of immune-mediated disorders and inflammatory diseases. This review reports the new developments with specific reference to the metabolic and signalling mechanisms associated with the complex immune-regulatory effects of vitamin D3 on immune cells.

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References

Bergman P, Walter-Jallow L, Broliden K, Agerberth B, Soderlund J . The antimicrobial peptide LL-37 inhibits HIV-1 replication. Curr HIV Res. 2007; 5(4):410-5. DOI: 10.2174/157016207781023947. View

Sadeghi K, Wessner B, Laggner U, Ploder M, Tamandl D, Friedl J . Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. Eur J Immunol. 2006; 36(2):361-70. DOI: 10.1002/eji.200425995. View

Ren S, Nguyen L, Wu S, Encinas C, Adams J, Hewison M . Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis. J Biol Chem. 2005; 280(21):20604-11. DOI: 10.1074/jbc.M414522200. View

Norman A, Mizwicki M, Norman D . Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model. Nat Rev Drug Discov. 2004; 3(1):27-41. DOI: 10.1038/nrd1283. View

Sly L, Lopez M, Nauseef W, Reiner N . 1alpha,25-Dihydroxyvitamin D3-induced monocyte antimycobacterial activity is regulated by phosphatidylinositol 3-kinase and mediated by the NADPH-dependent phagocyte oxidase. J Biol Chem. 2001; 276(38):35482-93. DOI: 10.1074/jbc.M102876200. View

Penna G, Amuchastegui S, Giarratana N, Daniel K, Vulcano M, Sozzani S . 1,25-Dihydroxyvitamin D3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells. J Immunol. 2006; 178(1):145-53. DOI: 10.4049/jimmunol.178.1.145. View

Torchia J, Glass C, Rosenfeld M . Co-activators and co-repressors in the integration of transcriptional responses. Curr Opin Cell Biol. 1998; 10(3):373-83. DOI: 10.1016/s0955-0674(98)80014-8. View

Willheim M, Thien R, Schrattbauer K, Bajna E, Holub M, Gruber R . Regulatory effects of 1alpha,25-dihydroxyvitamin D3 on the cytokine production of human peripheral blood lymphocytes. J Clin Endocrinol Metab. 1999; 84(10):3739-44. DOI: 10.1210/jcem.84.10.6054. View

Lemire J . Immunomodulatory actions of 1,25-dihydroxyvitamin D3. J Steroid Biochem Mol Biol. 1995; 53(1-6):599-602. DOI: 10.1016/0960-0760(95)00106-a. View

10.

Vidyarani M, Selvaraj P, Jawahar M, Narayanan P . 1, 25 Dihydroxyvitamin D3 modulated cytokine response in pulmonary tuberculosis. Cytokine. 2007; 40(2):128-34. DOI: 10.1016/j.cyto.2007.08.005. View

11.

Griffin M, Xing N, Kumar R . Gene expression profiles in dendritic cells conditioned by 1alpha,25-dihydroxyvitamin D3 analog. J Steroid Biochem Mol Biol. 2004; 89-90(1-5):443-8. DOI: 10.1016/j.jsbmb.2004.03.039. View

12.

Ralph A, Kelly P, Anstey N . L-arginine and vitamin D: novel adjunctive immunotherapies in tuberculosis. Trends Microbiol. 2008; 16(7):336-44. DOI: 10.1016/j.tim.2008.04.003. View

13.

Steinbrink K, Graulich E, Kubsch S, Knop J, Enk A . CD4(+) and CD8(+) anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity. Blood. 2002; 99(7):2468-76. DOI: 10.1182/blood.v99.7.2468. View

14.

Majak P, Rychlik B, Stelmach I . The effect of oral steroids with and without vitamin D3 on early efficacy of immunotherapy in asthmatic children. Clin Exp Allergy. 2009; 39(12):1830-41. DOI: 10.1111/j.1365-2222.2009.03357.x. View

15.

Zugel U, Steinmeyer A, May E, Lehmann M, Asadullah K . Immunomodulation by a novel, dissociated Vitamin D analogue. Exp Dermatol. 2009; 18(7):619-27. DOI: 10.1111/j.1600-0625.2009.00845.x. View

16.

Sahin G, Yasar N, Sirmagul B, Bal C, Yalcin A . The effect of low-dose cholecalciferol and calcium treatment on posttransplant bone loss in renal transplant patients: a prospective study. Ren Fail. 2008; 30(10):992-9. DOI: 10.1080/08860220802406369. View

17.

Steinstraesser L, Tippler B, Mertens J, Lamme E, Homann H, Lehnhardt M . Inhibition of early steps in the lentiviral replication cycle by cathelicidin host defense peptides. Retrovirology. 2005; 2:2. PMC: 548510. DOI: 10.1186/1742-4690-2-2. View

18.

Amadi-Obi A, Yu C, Liu X, Mahdi R, Clarke G, Nussenblatt R . TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat Med. 2007; 13(6):711-8. DOI: 10.1038/nm1585. View

19.

Cordes T, Diesing D, Becker S, Diedrich K, Reichrath J, Friedrich M . Modulation of MAPK ERK1 and ERK2 in VDR-positive and -negative breast cancer cell lines. Anticancer Res. 2006; 26(4A):2749-53. View

20.

Wang T, Dabbas B, Laperriere D, Bitton A, Soualhine H, Tavera-Mendoza L . Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease. J Biol Chem. 2009; 285(4):2227-31. PMC: 2807280. DOI: 10.1074/jbc.C109.071225. View