Regulation of Ferroptosis in Cancer and Immune Cells

Overview

Journal Immune Netw

Specialty Allergy & Immunology

Date 2025 Mar 13

PMID 40078787

Authors

Naeyoon Jang

Il-Kyu Kim

Dawoon Jung

Yeonseok Chung

Yun Pyo Kang

Affiliations

Soon will be listed here.

Abstract

Ferroptosis, an iron-dependent form of regulated cell death, is driven by lipid peroxidation and shaped by metabolic and antioxidant pathways. In immune cells, ferroptosis susceptibility varies by cell types, lipid composition, and metabolic demands, influencing immune responses in cancer, infections, and autoimmune diseases. Therapeutically, targeting ferroptosis holds promise in cancer immunotherapy by enhancing antitumor immunity or inhibiting immunosuppressive cells. This review highlights the metabolic pathways underlying ferroptosis, its regulation in immune cells, its dual role in tumor progression and antitumor immunity, and its context-dependent therapeutic implications for optimizing cancer treatment.

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